Tag Archives: parkinsons-disease

Why do I have spasms and what do I do about them?

 

Why do I have spasms and what do I do about them?back-pain-921

 

There are many reasons you might have spasms and the hard, painful clenching of contracted muscle can hurt enough to wake you up in pain.  What you do is not the same for everyone

 

Overuse or overtraining can cause your body to go into spasm, especially if a nerve is involved.  This serves two purposes: it gives you temporary if somewhat distorted support and gets you to stop what you are doing.  Use an analgesic that reduces pain and moves blood like aspirin or Dr. Christopher’s Antispasmodic formula or a Chinese martial arts dit dat jiao trauma formula.

 

A dit dat jiao is a liniment or topical tincture made up of herbs that increase circulation (including microcirculation of the capillaries), release the muscle layer and relieve pain. If there is a lot of redness and swelling a cooling effect can be added with mint or menthol the first day since this relieves inflammation without the bad effects of ice.

 

There has been controversy about using ice when a spasm first starts.  Don’t.  In Chinese medicine ice has always been proscribed because it drives the pain in deeper while giving surface relief.  Blood can congeal (clot) deep inside, blocking the circulation necessary to nourish the tissue, so it takes longer to heal the spasm.  Heat both increases circulation and relaxes the spasm.  Western medicine has finally caught up with Chinese medicine, although some trainers and doctors have not yet caught up with the research.

 

Related to overuse is poor functional posture which over time stresses some muscles and produces weakness in others that ought to work together.  An example of this is “computer neck” where the SCM, trapezius and other neck muscles become rigid because the head is held too far forward.  Yoga, Pilates and MELT classes can work on correcting posture while structural integration can  separate conjoined fascia so that muscles can work independently. While nutrients and herbs can reduce pain it is important to improve the functional posture to eliminate the cause.

 

Lack of magnesium which is an endemic condition in America can also affect cramping. Dietary magnesium is down 50% in the last 30 years as soil has been depleted by industrial farming and erosion.  Oral magnesium is difficult to absorb and I have been able to reach good testable levels using Jigsaw Sustained Release capsules twice a day plus topical magnesium oil from the ancient Zechstein inland sea.  I also do periodic soaks in Epsom salts or Magnesium Chloride salts.

 

Lack of iron is also a cause of spasmodic leg shaking but should not be supplemented unless blood tests low.  The Chinese cure would be to eat liver for such Liver Wind conditions.

 

The widespread use of statins for cholesterol has led to a wholesale depletion in Ubiquinone (Coenzyme Q10,) the body’s natural antioxidant.  While statins have tested as useful for males who have had heart attacks, the usefulness for anyone else is unclear.  Cholesterol is the body’s natural bandage for inflamed arteries and is the building block of steroid hormones and brain tissue, so there are good reasons to not lower it.  Statin use is known to frequently lead to muscle pain and more rarely rhabdomyolysis, a severe condition which affects the muscles.  The most common signs and symptoms of rhabdomyolysis include:

 

  • Severe muscle aching throughout the entire body
  • Muscle weakness
  • Dark or cola-colored urine

 

The higher the dose of statins, the higher the risk of rhabdomyolysis becomes. The risk also increases when taken in combination with certain drugs.

 

Low B vitamins can also cause spasms. Try methylfolate instead of folic acid and methylcobalamin instead of normal B12, particularly if you know you have the MTHFR gene snip.  (If you don’t know I’d take these forms anyway.) Low doses three times a day are best and take a methylated B complex.

 

Although it does not seem intuitive, eating gluten can cause muscle and joint pains. Once the inflammatory proteins get past a leaky gut they circulate with the blood all over the body, causing pain

 

Diseases like Parkinson’s and Essential tremor can cause hard spasms due to the continual shaking.  Work on increasing liposomal glutathione, CoQ10, Vitamin C and Folate as well as a full component of minerals, detoxification and exercise.

 

Body work is very important. Deep massage, myofascial work, bonesetting tuina or chiropractic can make a great impact on nerve-related or muscle work.

 

Acupuncture is very good for spasms, on both a local and distal level.  It is not necessary to needle directly into a spasm, but if the spasm is not too hard or sensitive,

 

 

local needling can increase circulation into the spasm.  But needling on the opposite side, along the meridian or into special points can signal the brain to release muscles or endorphins.

 

 

 

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Getting Through the Blood Brain Barrier

BBB and nose limbic systemPeople have been asking how the stem cells go past the blood brain barrier to get to the substantia nigra where dopamine is made. Stem cells are not supposed to be able to cross the BBB, which is why early stem cell treatment for Parkinson’s was not broadly successful.But it seems that the Blood Brain Barrier is less a barrier than a regulator which can at times be selective in what it lets through.Now it isn’t clear to me whether the stem cells actually go through the BBB or just signal cells on the other side but it does appear to make a significant difference clinically.  I think they do get through based on the research cited below.

 There are three primary sorts of barriers of the BBB, the vascular brain barrier, blood-CSF barrier, and the specialty CNS barriers such as the blood-retinal barrier.  They transport molecules in by pores, the opening of tight junctions and receptors. (1) One can also bypass the BBB by going through the nose or injecting directly into the cerebral spinal fluid. This even works for larger molecules like peptides and other proteins.(1) Injecting insulin through the nose has been helpful for Alzheimer’s for instance. And they injected stem cells into the middle turbinate of my nose as one form of administration. It was weird but topical lidocaine prevented pain.

BBB and junctions
Ways through the Blood Brain Barrier

However researchers also found that mannose IV infusions open pores in the BBB and increase enzyme passage 10 fold (2). In fact mannose infusion has become a standalone therapy as well as a way of getting drugs to the brain.

StemGenex, the center that performed my stem cell administration, started using mannose infusions long before they started using intranasal injection. It increased the success for neurological conditions. Their mannose solution increases the diameter of pores for 20 minutes, so it is immediately followed by injected and IV stem cell administration.

English: The Blood Brain Barrier and Astrocyte...
English: The Blood Brain Barrier and Astrocytes type 1 (Photo credit: Wikipedia)

If you are academically inclined, the following articles give the science behind getting through the BBB. Our understanding of the BBB is growing every day.

 

 

And if you would be so kind as to help fund my Parkinson’s stem cell transplant: http://www.gofundme.com/eg4ymk

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The Stem Cell Implant

Karen Rita Alexander and Dr RavdenSo I had the procedure yesterday. In the morning they took blood and did the mini liposection. I was sedated without loss of consciousness. It was laparoscopic with two tiny incisions, filled with saline and epinepherine then fat cells were extracted. They wrapped my abdomen in a stiff binder and took me to the recovery room. After recovery, while the cells were processed, laser and enzyme activated and mixed with Platelet Rich Plasma, they gave me an infusion of mannose to open the blood brain barrier. Apparently they started this practice before having used the intranasal administration and found great improvement in neurological patients.

The cells came back in a mini IV bag of pink liquid and a group of syringes, one for each of the points we had selected and a catheter for the bladder (the only real painful procedure.) I prevailed upon him to stick me at St. 36 for stamina and he was already using Liver 3 for my toe that has been bursting through the cartilage since the Parkinson’s Walk two years ago.

The IV was somewhat curtailed since I have small veins. The nurse decided that I already had a few billion stem cells, so she drew it out of the IV tube into the syringe. I considered self-injection (and ought to have asked for the doctor to inject more into my chronically stiff neck. )

There is more and the staff was interested in how acupuncture can reduce scars and deal with neurological conditions. The medical director said she was told by a Chinese acupuncturist that acupuncture stimulates the activity of stem cells (albeit at a lower concentration.) Silberstein, M. (2009). The cutaneous intrinsic visceral afferent nervous system: A new model for acupuncture analgesia. Journal of Theoretical Biology, 261(4), 637–642. doi:10.1016/j.jtbi.2009.09.008

 

And if you would be so kind as to help fund my Parkinson’s stem cell transplant: http://www.gofundme.com/eg4ymk

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Gut Bacteria, Parkinson’s and Stem Cells

350px-stem_cell_treatments-svgI found two exciting pieces of research this week that will affect my treatment. If you have been following me you will know that I am fascinated with the gut bacteria and the other tiny creatures that account for 90% of our DNA. The gut/brain interface is more fascinating than you might imagine!

The first study from the University of Helsinki found that the gut bacteria- the microbiome- of people with Parkinson’s is different than that of healthy people.  We have more of some bacteria- which increase the worse the symptoms get and others have gone missing, relatively speaking.

The more Enterobacteriaceae we have, the more severe the symptoms. A lack of Prevotellaceae bacteria in Parkinson’s sufferers could mean these bacteria might have a property which protects their healthy hosts from the disease. This seems strange since I generally consider Prevotellaceae to be a sign of inflammation. Or does this discovery merely indicate that intestinal dysfunction is part of the pathology? It might be a result of Parkinson’s disease.

The second piece of research in Blood, the Journal of the American Society of Hematology, shows that people with more gut bacteria do better with stem cell transplants. The more diverse the microbiome, the better the stem cells take. This of course gets me questioning the pre-op antibiotics that StemGenex recommends. Next stop is sending them the research!

Now given that a healthy gut should have some 10,000 species according to Martin Blaser’s book Missing Microbes  and a functioning biofilm, taking a probiotic with a maximum of 13 species of lactobacillis and bifidobacteria isn’t going to make it. I do like to take Saccharomyces boulardii which tends to be under-represented and soil based probiotics  for the same reason. And to eat Jerusalem artichokes which help them grow.  So I am onto my fermented food regimen which allows for unnamed wild species: full fat unsweetened yogurt from different animal milks, olives, miso of various sorts, blue cheese, kombucha, fermented veggies, kimchee, pickles, refrigerated sauerkraut and raw milk products.

Here is the summary of the research:

Gut Microbiota and Parkinson’s Disease:  Connection Made

 

And if you would be so kind as to help fund my Parkinson’s stem cell transplant:  http://www.gofundme.com/eg4ymk

 

 

 

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Watermelon and Papaya for Parkinson’s

Incidentally I have found two new foods that diminish Parkinson’s tremors: watermelon and papaya. I learned about them from a Parkinson’s blogger who calls herself Aunt Bean (after the fava and mucuna beans she grows for PD.) Apparently the late pope used fermented papaya and Aunt Bean has a recipe here. I started out fermenting them. Watermelon was easy: I scooped the pulp into a blender, liquified it and added water kefir grains. It soon turned into a bubbling sour drink. The papaya was harder: I mashed the pulp and fermented it but needed to dry it on fruit leather trays which I don’t have for my dehydrator.

California Papaya grown in Indonesia, cut into...
California Papaya grown in Indonesia, cut into half (Photo credit: Wikipedia)

But I also read comments that the unfermented food worked and I noticed that raw watermelon and papaya seemed to reduce tremors. Fermentation does reduce sugar and add probiotics but it doesn’t keep very long. So my dehydrator is going, full of papaya slices  (the watermelon is done.)

Now I had no idea why watermelon and papaya work, and they are hardly a cure. But it was tasty and easy to incorporate into a daily diet. I still take the fava beans (note that dopamine medication could interact) but I don’t take them every day any more.

So I went on a search.  In Chinese Medicine watermelon is considered a cold medicinal herb, used to drain heat out of the body through the urine and to replenish fluids. Xi gua (watermelon) is known to clear heat, replenishes fluids, regulate urination and expel jaundice- it is used in hepatitis treatment. While the materia medica says that it goes to the Heart, Bladder and Stomach but not the liver, the attributes or meridians named after organs are not identical with those attributed to organs by Western medicine   The jaundice and hepatitis indications made me think of the liver and I guessed that glutathione production might be affected. And in fact while I still needed to check scholarly sources, Dr. Oz cites watermelon as a rich source of glutathione. And although short-lived and poorly absorbed from pills, glutathione does reduce tremors.

Watermelon provides 28 milligrams of glutathione per 100 gram portion. A perusal of PubMed shows that watermelon extract can mitigate oxidative damage from X-rays or genotoxicity and neurological balance. To use or make glutathione we need water which is in abundance in watermelon. If we are dehydrated we may not make as much glutathione as we could.

Now papaya fruit is not in the Chinese Materia Medica, but I checked PubMed using “Papaya and Glutathione” as search terms.  And, Bingo!  “A glutathione S-transferase inducer from papaya: rapid screening, identification and structure-activity relationship of isothiocyanates.”  Papaya induces glutathione.

Seedless watermelon Purchased Feb. 2005 in Atl...
Seedless watermelon Purchased Feb. 2005 in Atlanta, GA, USA The tag had the following information: mini me (TM) AYACO FARMS PERSONAL SEEDLESS WATERMELON #3421 PRODUCT OF NICARAGUA (Photo credit: Wikipedia)

Glutathione, a compound containing three amino acids, glutamate, cysteine and glycine, is the body’s master antioxidant and when its production is damaged a variety of things can go wrong including tremors. IV glutathione is given in a push to stop symptoms of Parkinson’s Disease but the IVs are recommended 3-7 times a week, not covered by insurance.  The landmark glutathione Parkinson’s study, Reduced intravenous glutathione in the treatment of early Parkinson’s disease., was done by the Department of Neurology, University of Sassari, Italy in 1996. In this study all patients improved significantly after glutathione therapy with a 42% decline in disability.  Neurologist Dr. Daniel Perlmutter has been giving it to PD patients since 1998. 

Now I would not be so reductionist as to say that it is only glutathione that makes watermelon or papaya work.  Watermelon hydrates which provides the a matrix for the hydronium ions that carry qi through fluids,  It is high in flavanoids Vitamin A, Vitamin C, B vitamins, and potassium, not to mention cirtulline and lycopene, One slice of watermelon (485 g) contains 152 calories, 3 g protein, 34.6 g carbohydrates, 2.4 g fiber, 560 mg potassium, 176 mg vitamin A (RE), 47 mg vitamin C, 8..5 mg choline, 0.1 mg riboflavin, and 0.96 mg niacin.

Papaya contains enzymes that induce glutathione S-transferase. Papaya latex contains at least four cysteine endopeptidases and other constituents including hydrolase inhibitors and lipase.  It has rather high levels of potassium and significant levels of calcium and magnesium. Vitamin C, Vitamin A. A small fruit (157  g) contains 67 calories, 0g protein, 17 g carbohydrates, 2.7 g fiber, 286 mg potassium, 1531 IU vitamin A (RE), 86.5 mg vitamin C, 15 mg folate and 0.5 mg niacin. Since the enzymatic effect is important one should avoid irradiated papayas to get the best effect.

There is evidence that a yeast fermented preparation of papaya is more effective than fresh or dried papaya.  It reduces oxidative stress and has been found to protect the brain from oxidative damage in hypertensive rats.  Pope John Paul ll was prescribed an experimental treatment made from a fermented papaya to ease symptoms of Parkinson’s disease, I suspect that the fermentation makes a difference compared to dried or raw papaya.

So incorporating watermelon and fermented papaya is an easy way to reduce symptoms. Other fruits that also have glutathione and are rich in antioxidants are berries, oranges, pomegranate, apricots, prunes,  avocado, grapefruit, strawberries, peaches, cinnamon, asparagus,  legumes, nuts, spinach and bell peppers. Or eat cysteine-rich food including dairy products such as cheese,yogurt and chicken breast since cysteine is used in glutathione synthesis. Add a couple of  Brazil Nuts for selenium (or tuna, beef, walnuts, eggs, cottage cheese, or turkey) and we are set!

 

See Also:

Experimental Treatment for Parkinson’s

Nutrition for Parkinson’s Disease- Part 1

2

Eating Watermelon for Parkinson’s Symptoms

Papaya and watermelon
Papaya and watermelon (Photo credit: Wikipedia)

 

 

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Experimental Treatment for Parkinson’s

Diseases and conditions where stem cell treatm...
Diseases and conditions where stem cell treatment is promising or emerging. (See Wikipedia:Stem cell#Treatments). Bone marrow transplantation is, as of 2009, the only established use of stem cells. Model: Mikael Häggström. To discuss image, please see Template talk:Häggström diagrams (Photo credit: Wikipedia)

I was diagnosed with Parkinson’s Disease 6 years ago. I am working as an acupuncturist, herbalist and health writer, which all require a steady hand. I have been helping run free clinics since 9-11 and do a lot of public health education on Facebook and my blog Natural Health by Karen and teach as an adjunct professor at NY College for the Health Professions. My private practice specializes in complicated conditions which is rewarding but not lucrative. At best this is a breakeven proposition so my funding for treatment is limited. I have mastered the art of ambidextrous needling and the tremor only happens at rest but the tremor is starting to spread to the other side and it will eventually affect my ability to treat patients.

I have found a promising experimental stem cell trial by StemGenex in La Jolla, California that has a special affinity for Parkinson’s and other neurological diseases. Unlike most stem cell treatment centers they use an intranasal administration to get stem cells to the brain, either traversing or signalling beyond the blood brain barrier.The treatment was pioneered for Alzheimer’s and works for that disease. They do this along with intravenous and direct injections and their internal statistics on Parkinson’s patients are much better than others since getting the stem cells into the brain is difficult. I would like to participate in the trial for this promising procedure.

I have been pre-approved for treatment but insurance will not cover experimental procedures (and trials on procedures are not covered by drug companies!)

The cost of treatment is $15,900 plus air fare of $800 and $1000 for a course of hyperbaric treatment as aftercare.

I will write in detail about the experience, documenting it with video and making medical information available regardless of outcome. This will help others considering stem cell treatment. I will focus on what can be done to enhance the treatment, based on interviews with patients, doctors and my own experiences.

If you know someone with Parkinson’s, would like to advance the medicine, want to help me or just want to do a mitzvah, I would be very grateful. If you know someone else who might help please pass this on.

Thank you for reading this far. I must acknowledge that I am a bit bewildered by this new way of dealing with health care (and hope it doesn’t sound tacky to ask for help,) but I appreciate your interest.

Donations to Paypal at ksvaughan2@aol.com  or Go Fund Me

See also:

Nutrition for Parkinson’s Disease- Part 1

2

Watermelon and Papaya for Parkinson’s

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What Not To Eat With Parkinson’s Disease,Part 2

In Part 1 I discussed what to eat if you have Parkinson’s Disease. PD is only partially genetic and can be induced by exposure to pesticides, herbicides and other chemicals, some of which are found in food.

This is what to avoid:

  • Sugar Dish
    Sugar Dish (Photo credit: Steve Snodgrass)

    Aspartame, Neotame, Nutrasweet, Sugar Twin, Equal, or Spoonful which degrade to neurotoxins when exposed to heat over 86°F or 30°C (and they don’t ship soft drinks in refrigerated trucks.)  At that temperature aspartame breaks down to aspartic acid and phenylalanine and a small amount of methanol (wood alcohol) – which degrades to formaldehyde.  There is some evidence that reaction to the sweeteners results in diagnoses, or misdiagnoses of Parkinson’s or MS and anecdotal evidence of at least some people reverting to normal after removing it.  In any event you don’t want to add neurotoxins to your PD as they may be part of the cause.  Also look at dental and pharmaceutical supplies that may contain the sweeteners.

  • Sucralose is probably more heat stable than aspartame, but I would avoid it as well as saccharine (Sweet n Low) on general health principles.  Instead use stevia, lo han guo or 100% fruit juice (in moderation).  Water of course is best, but if you want some taste try inserting a spear of watermelon and a sprig of mint, or cut up citrus fruit into your jug. For electrolytes I often squeeze 10 drops of Trace Mineral Concentrate into a day’s dose as well and that also helps provide micronutrients needed for enzymatic activities in the brain and body.
  • Sugar.  Scientists believe that dementia in Parkinson’s disease occurs as a result of a defect in how the brain metabolizes glucose, or blood sugar. Chronically high blood sugar levels may also be involved in the onset of Parkinson’s disease. One role of the insulin in the brain is to regulate dopamine. When the brain’s insulin receptors become defective, insulin cannot regulate the system which inhibits the secretion of dopamine.
  • Food sprayed with pesticides, herbicides or fungicides.  These are quite often neurotoxic or endocrine disruptors and can be problematic in PD
  • Round-up ready anything.  This line of genetically modified organisms (GMOs) are engineered with pesticides in every cell and have been linked to problems in animals including including infertility, immune problems, accelerated aging, faulty insulin regulation, and changes in major organs and the gastrointestinal system. The Institute for Responsible Technology says:

There are eight GM food crops. The five major varieties—soy, corn, canola, cotton, and sugar beets—have bacterial genes inserted, which allow the plants to survive an otherwise deadly dose of weed killer. Farmers use considerably more herbicides on these GM crops and so the food has higher herbicide residues. About 68% of GM crops are herbicide tolerant.The second GM trait is a built-in pesticide [Round-up], found in GM corn and cotton. A gene from the soil bacterium called Bt (for Bacillus thuringiensis) is inserted into the plant’s DNA, where it secretes the insect-killing Bt-toxin in every cell. About 19% of GM crops produce their own pesticide. Another 13% produce a pesticide and are herbicide tolerant…

The biotech industry claims that Bt-toxin is harmless to humans and mammals because the natural bacteria version has been used as a spray by farmers for years. In reality, hundreds of people exposed to Bt spray had allergic-type symptoms,[12] and mice fed Bt had powerful immune responses[13] and damaged intestines.[14] Moreover, the Bt in GM crops is designed to be more toxic than the natural spray and is thousands of times more concentrated.

  • Rats fed GM potatoes had smaller, partially atrophied livers.[24]
  • The livers of rats fed GM canola were 12-16% heavier.[25]
  • GM soy altered mouse liver cells in ways that suggest a toxic insult.[26] The changes reversed after they switched to non-GM soy.[27]
  • More than half the babies of mother rats fed GM soy died within three weeks.[28]
  • Male rats[29] and mice[30] fed GM soy had changed testicles, including altered young sperm cells in the mice.
  • Thousands of sheep, buffalo, and goats in India died after grazing on Bt cotton plants after harvest. Others suffered poor health and reproductive problems.[34]
  • Farmers in Europe and Asia say that cows, water buffaloes, chickens, and horses died from eating Bt corn varieties.[35]
  • About two dozen US farmers report that Bt corn varieties caused widespread sterility in pigs or cows.[36]
  • Filipinos in at least five villages fell sick when a nearby Bt corn variety was pollinating.[37]
  • The stomach lining of rats fed GM potatoes showed excessive cell growth, a condition that may lead to cancer. Rats also had damaged organs and immune systems.[38]
  • You can avoid major exposure to these by growing your own or purchasing organic foods, which are best for persons with Parkinson’s.  If you can’t, look for the Clean 15 foods which tend to have inedible skin or are naturally resistant to pests:  onions, non-GMO sweet corn, avocados, pineapple, mango, asparagus, kiwi, cabbage, eggplant, watermelon, papaya, sweet onions, grapefruit, and sweet potato.  Always wash by first dipping into a solution of water and pure soap, then rinse with water alone as was done for the Clean 15 and Dirty Dozen lists.
  • To reduce pesticide exposure by 80% avoid or get organic versions of the Dirty Dozen high-pesticide foods defined by the Environmental Working Group :

    The fruits and vegetables on “The Dirty Dozen” list, when conventionally grown, tested positive for at least 47 different chemicals, with some testing positive for as many as 67. For produce on the “dirty” list, you should definitely go organic — unless you relish the idea of consuming a chemical cocktail. “The Dirty Dozen” list includes: celery, peaches, strawberries, apples, blueberries, nectarines, sweet bell peppers. spinach, kale and collard greens, cherries, potatoes, imported grapes, lettuce

  • A bowl of Strawberries. Français : Un bol de f...
    A bowl of Strawberries. Strawberries depend on pesticides and fungicides to ship from across the country. (Photo credit: Wikipedia)

    Meat that is conventionally raised is much worse than conventionally raised fruits and vegetables because it concentrates the toxins of the food it eats in fat.  So if your organic dollar is limited, use it for any meat and dairy that you consume.  Chicken is especially problematic.  You want grass-fed, pastured meat and chickens raised mostly outdoors.

  • Avoid most farmed fish or fish not approved by Seafood Watch which monitors for mercury or heavy metals.  The lists are regional but avoid Chinese farmed shellfish especially.  Smaller fish are generally better than larger fish higher up the food chain. There is a free downloadable ap on the Seafood Watch site which will help for grocery shopping or dining out.
  • Seed oils in cooking which tend to go rancid with cooking heat.  This includes oils in processed foods or restaurants.  Cook with saturated coconut oil which doesn’t degrade with heat and use fragile Extra Virgin Olive Oil for salads.
  • Hydrogenated oils, partially hydrogenated oils, trans fats, margarine or rancid fats and oils.  Your brain is mostly fat.  Give it good fats and cold pressed oils.
  • Don’t eat fava beans unless you regulate your medicines to regularly include them in your diet.  Fava beans can increase L-doppa levels and that could result in too much.
  • Avoid excitotoxins like MSG which may agitate your brain increasing tremors.
  • Too low a salt level can cause hyponaturemia.  As PD progresses, muscles spasm and it becomes hard to drink.  Medications can also deplete salt and mineral levels.  Use a full-spectrum mineral salt like Himalayan salt or grey Celtic sea salt.
  • Anti-nutrients like high levels of oxalates in rhubarb or spinach and phytates in unfermented beans.
  • Junk food which has low levels of nutrients in the first place.  You need antioxidants, minerals and fiber to detoxify.  Processed food gives you very little of any and is a prime source of GMO foods, excitotoxins like MSG, chemical stabilizers and fillers.
  • Gluten, soy, dairy or any other allergenic food one may be sensitive to.  Allergens produce inflammation and inflammation can drive Parkinson’s.  This needs  to be individualized and the best way to test is to write down and rate your symptoms then go off a suspect food 100% for a month and rate the symptoms again.

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Nutrition for Parkinson’s Disease- Part 1

Nutrition for Parkinson’s Disease has four components: What to Eat, What Not to Eat, Useful supplements and How to Eat, given symptoms of the disease.  This will be a four piece series.  Some of it is basic: the foods and superfoods that enrich the diet.  Some is specific to the typical complaints from either the disease, the medications and the often restrictive lifestyles that PD patients often adopt.   And the how-to acknowledges that the disease creates some physical problems that adaptive devices might help.

Mucuna
Mucuna in flower, source of L.Dopa (Photo credit: Wikipedia)

Nutrition for Parkinson’s Disease Part 1:  What to Eat

People with Parkinson’s have some extra requirements in their diet.  Because shaking can burn calories, it is easy to become underweight, although that is not universal.  Yin deficiency, a kind of dehydration or wasting, is generally seen in symptoms like shaking, muscle spasms, constipation, poorly nourished muscles and skin, as well as dehydration.  Blood deficiency can be seen with pale skin, lips and tongue as well as with muscle wasting. While we have limited knowledge of what causes the substantia nigra to stop making dopamine, it is likely that missing nutrients will be implicated in both the production of dopamine and the preservation of brain cells. People with Parkinson’s often suffer from constipation and muscle  spasms. So what should you eat?

  • Berries and other fruits-  While people with Parkinson’s who are not overweight can eat fruit rather freely, it is best to deal with nutrient-dense berries.   Blueberries, huckleberries, goji berries, blackberries, raspberries, organic strawberries,  pomegranates, and cherries all pack a deeper nutritional punch than apples, pears and bananas.  All are useful, but especially the berries which are rich sources of flavonoids.  Blueberries and organic strawberries can reduce depression, improve memory and slow neuro-degeneration. Goji berries are especially high in antioxidants and can build blood.  Cranberries may protect the urinary tract. Tart cherries can help insomnia with their melatonin. Berries can pack in the nutrition especially as swallowing becomes more difficult.  Go for organic, especially with strawberries and other berries because chemicals in pesticides can be linked to Parkinson’s. All fruits provide fiber which can counteract constipation. 1/2-1 cup daily.
  • Purine-rich foods which break down too uric acid and then urates:  The chemical urate, a potent antioxidant which is known to cause gout in excess, appears to slow the progression of Parkinson’s disease.  Foods that make uric acid include:  fructose, asparagus, beer, heart, herring,mussels,yeast, smelt, sardines, and sweetbreads.  Just don’t overdo it, especially if you are prone to gout or insulin resistance.  A serving a day, but take it in the evening if you are on Levodopa or Carbodopa.
  • Fatty fish or fish oil including halibut, sardines, wild Alaskan salmon, anchovies and herring are rich in the DHA and EPA, Omega 3 fatty acids which go to the brain and help guard against dementia which affects some 40% of people with Parkinson’s.  Fish oil improves cognition, protects against depression, boosts the immune system,relieves arthritis and protects the heart.  I do not find flax oil as effective as fish or cod liver oil- it can require 30 times the dose, goes rancid very rapidly and some 30% of the population cannot convert it to DHA.  (DHA makes up 20% of grey matter in the brain.)  If you eat fish, eat the skin and check Seafood Watch to make sure that mercury levels are low. Beef that is 100% pasture-raised on grass has a fat profile similar to deep water fish but conventionally grain-raised CAFO beef does not.  Otherwise get cod liver or fish oil and take enough to get 1000 mg of DHA. Since that can be 5 capsules, I generally get Carlson’s lemon-flavored fish oil or Green Pasture’s cinnamon fermented cod liver oil and use it to wash down supplements.
  • Iron is linked to dopamine production.  Patients with Parkinson’s have lower levels of dopamine produced by the substantia nigra and may respond to iron administration. Iron, as a cofactor in dopamine production, plays a central role in the etiology of the disease. Low dopamine can cause other neurological problems such as restless leg syndrome and muscle spasms.  Judging from the Parkinson’s people I see, Blood Deficiency is pretty  widespread. I recommend pasture-raised organic red meat, liver once a week,and dark green and dark red vegetables. (Chlorophyll is hemoglobin with magnesium at the center instead of iron, but usually has non-heme iron as well.)  To increase iron absorption, tincture of Yellow dock (Rumex crispus) given in drop doses to stomach tolerance, can be helpful. However taking iron as a supplement can be ineffective (hard to absorb), hard on your heart or absorbed by bad gut flora.  Dr.Campbell-McBride advises against it :

 Most people with abnormal gut flora have various stages of anemia. It is not surprising. They not  only can’t absorb essential for blood vitamins and minerals from food, but their own production of these vitamins is damaged. On top of that people with damaged gut flora often have a particular group of pathogenic bacteria growing in their gut, which are iron-loving bacteria (Actinomyces spp., Mycobacterium spp., pathogenic strains of E. coli, Corynebacterium spp., and many others). They consume whatever iron the person gets from the diet, leaving that person deficient in iron. Unfortunately, supplementing iron makes these bacteria grow stronger and does not remedy anemia.” (Gut & Psychology Syndrome)

Vinegars made with live mothers are probiotic
  • Probiotic Foods help you develop good gut flora that can out-compete undesirable bacteria and to increase digestion.  Live blue cheese, yogurt, kefir, sauerkraut, kimchee, vinegar with a mother like Braggs, kombucha, unpasturized  pickles and olives, miso, fermented fish sauces and pickled vegetables should be taken at each major meal.  Pickles and pickle juice helps the body free up magnesium which can reduce cramps.  Other bacteria help absorb minerals.  I prefer food-based sources of probiotics because you eat them fresh, they come with their own prebiotics which feed them and tend to have a variety of organisms that may not be in pill form.  For instance, most probiotic pills only have lactobacillus or bifidobacteria but there may be another 500 species that are present in a healthy gut. If you do use probiotic supplements, look for them in a refrigerated case rather than a shelf.
  • Prebiotic foods feed the gut flora and can protect against iron depleting strains of bacteria.  Prebiotics like  fructooligosaccharide (FOS) and inulin feed the probiotic organisms and allow them to proliferate in the gut.  They ought to be in probiotic supplements to help keep them alive.  However your gut also needs to be receptive to them.  Rather than purchasing a prebiotic supplement, eat a serving of Jerusalem artichokes, asparagus, onions, leeks, burdock root, garlic (in quantity), shallots, jicama root, chicory or dandelion root, barley or yacón each day.
  • Nuts from trees are great sources of Vitamin E in its various forms and trace minerals, as well as good fats provided you eat them raw.  Roasting can easily change the fat profile and excessive conventional salt triggers indiscriminate consumption.  You will absorb nut nutrients better if you soak them overnight- you can puree them into nut butter with a little sea salt, toss them into salad or a stir fry or make your own nut milks. They are storehouses of important trace minerals:  Brazil nuts are high in selenium which can help the heart.  Peanuts which are ground nuts are significantly contaminated with aflatoxin, a known carcinogen that is twenty times more toxic than DDT. Since toxins can cause some Parkinson’s, avoid peanuts. 1 oz . per day of tree nuts.
  • Beans in general are good for Parkinson’s because the fiber levels are high enough to prevent constipation while providing protein, reducing blood sugar spikes and providing  protection from cancer. They can be consumed daily with herbs like rosemary or bay leaf to reduce flatulence and making them yourself will allow you to change the water enough to reduce that problem.  But there are two beans in particular which provide special protection against Parkinson’s:  fava beans and mucuna beans.   These beans contain levodopa, the same chemical in Sinemet, Madopar, Dopar, Larodopa, and other levodopa-containing medicines used to treat PD which means that adding them to a well-balanced prescription can be problematic, although they can sometimes substitute for all or part of a prescription. According to Dr. Jame’s Duke’s database the entire fava plant, including leaves, stems, pods, and immature beans, contains levodopa, with the highest concentrations in the flowers and sprouting bean. The amount of levodopa can vary greatly, depending on the species of fava and where it’s grown especially since it has been cultivated as a food rather than a medicine for most of its history.  Three ounces (about 84 grams or ½ cup every day) of fresh green fava beans, or three ounces of canned green fava beans, drained, may contain about 50-100 mg of levodopa. One small study showed that mucuna had better results than the form of levodopa given as prescription medication and anecdotal evidence shows it tends to work better than fava beans. Doses range from 22.5 – 67.5 g per day divided in 2 – 5 doses.  Neither bean should be taken by persons with Monoamine oxidase inhibitors (MAOI) or elevations in blood pressure may result.  If you have favism, a genetic susceptibility where you lack an enzyme called glucose-6-phosphate, eating fava beans could cause a condition called hemolytic anemia.  This is ruled out by a test but it is unknown if mucuna also causes this reaction.  Lacking either MAOIs or Favism, both beans are potentially good for people with  Parkinson’s who work with an herbalist and medical doctor.
  • Cruciferous Vegetables like broccoli, cauliflower, cabbage, kale, bok choi, kohlrabi, brussels sprouts and mustard, rutabaga and turnip greens help reduce estrogen dominance which reduces magnesium and vitamin B. A deficiency in magnesium causes muscle tightening and that causes people to experience  muscle spasms while deficiency in vitamin B can cause neurological problems like neuropathy.  Cruciferous vegetables are rich in zinc, vitamins A, B, C, D and E and  Indole-3-Carbinol (I3C) which is especially beneficial to estrogen metabolism. When I3C combines with stomach acid it creates 3,3-Diindolylmethane, or DIM. The metabolism of DIM overlaps with estrogen metabolism so that it promotes healthy estrogen metabolism.  Eat 2-4 servings daily within your 9 servings of veggies and berries.  They should be steamed or in the case of kale chips, dried with heat to protect the thyroid.

  • Coffee and Tea. Coffee has shown to be helpful at both preventing and slowing the progression of Parkinson’s disease in a dose-dependent way.   Coffee consumption is associated with 60% fewer cases of Parkinson’s Disease in one study. Caffeinated coffee is better than decaf and coffee reduces symptoms better than other sources of caffeine, indicating that caffeine alone may not be the protective mechanism. (Coffee is much more than caffeine, with magnesium and potent antioxidants like the chlorogenic acids.) Caffeine as an isolate incidentally was associated with better motor control but had very little effect on daytime sleepiness.  One caveat:  some people don’t do well on coffee and tend to self-select out of  the positive scientific studies (try making a coffee placebo!) Follow your own body.  Tea has general health benefits from catechins which are powerful antioxidants and at least one study showed a reduced risk of Parkinson’s disease.  There is some evidence that symptoms may be reduced with tea drinking, especially in studies of Asian populations.
  • Other Fluids:  Since dehydration is a problem, you need to drink.  Drinking more than a half cup at a time triggers the urinary reflex so does not hydrate your tissues.  So put your water in a bottle with a drink-through cap and sip it  through the day.  If you drink coffee or soda, assume that the caffeine will reduce hydration by 25% and tea or iced tea by 10%.  Don’t drink soda though, especially cola or artificially sweetened soda which contains potential toxins not known to be safe for Parkinson’s.  If water seems too plain, add a spear of melon and a sprig of mint, or sliced lemons or fresh rosemary and orange slices. Coconut water has a good balance of electrolytes and isn’t too sweet. You can also get fluids from fruits like watermelon or citrus.  But if you can get fresh vegetable juice with lots of greens, it would be better from a nutritional standpoint. Don’t forget good fats- think of oil floating on water to prevent evaporation.
Mai men dong (ophiopogon tubers) make a mild soup ingredient that strongly tonifies yin. Available at Chinese grocery stores.
  • Yin building herbs and foods:  Parkinson’s disease can be dehydrating, drying out skin, muscles, the colon and joints. This is referred to as yin deficiency and can develop into deficient (friction) heat as it progresses. You need to nourish your fluids and tissues and there are a number of “Chinese grocery store”  or food grade herbs and foods that can help.  Seaweeds should be included in the diet at least twice a week, but dulse, nori and kelp are also available as sprinkles that can be used like a flavored salt inbetween.  Seaweeds are good sources of trace minerals and iodine, since much of our healthy topsoil has blown out to sea.  A table spoon or two of slippery elm or marshmallow powder can be stirred into applesauce or oatmeal.  Mai men dong bulbs (opiophogon, liorope) are small, bland Chinese vegetables that nourish yin, go well in even western soup and can be found at Chinese grocery stores.  So can white lily bulb (bai wei), broken into small bulblettes.  Shatavari (asparagus tuber, tian men dong), the yin adaptogen food can be found online powdered, and can be used to thicken soups while nourishing fluids, hormones and tissues.  Oatmeal, millet, alfalfa sprouts, artichoke, asparagus, kelp, mung bean sprouts, okra; peas, potatoes, black beans, avocado, aduki beans, seaweed, string beans, sweet potatoes, tomatoes (especially tomato paste), water chestnuts, yam, zucchini, berries, apricots, pears, watermelon, fish and shellfish, pork (especially liver and kidneys), beef, goose and duck, coconut milk and nuts all will help keep you supple.  9 servings of  yin-tonifying fruits and vegetables a day.
  • Foods with B vitamins, especially B1 thiamine, B5 pantothenic acid, B9 folate, B12 cobalamin, B6 pyrodoxine help the mitochondria which power our cells . Foods high in B vitamins include purple and green kale, mushrooms, bok choy, collards, rare organ meats like liver, heart and tongue,  and very rare muscle meat.  Meats are better sources when organic and grass fed. However if you can’t find grass fed liver, the organ has numerous detoxification pathways so you are safe with conventional liver- akin to an apartment building with a full janitorial staff.  This is not true of other organs.
  •  Iodine is important for Parkinson’s.  It not only necessary for the production of thyroid hormone, it is also responsible for the production of all of the other hormones of the body. Adequate iodine levels are necessary for proper immune system function. Iodine contains potent antibacterial, antiparasitic, antiviral, and anticancer properties. Iodine deficiency disorder can result in mental retardation, goiter, increased child and infant mortality, infertility, and socioeconomic decline. There is evidence that Parkinson’s is more prevalent where iodine is missing in the soil and  in areas where goiters are frequent. Long-term iodine deficiency appears linked to abnormalities in the dopaminergic system that include an increased number of dopamine receptors. This raises susceptibility to dopamine oxidation which, in turn, causes deficiencies of the antioxidant enzymes Copper or Zink superoxide dismutase, glutathione peroxidase and catalase. Dopamine deficiency also leads to elevated cytotoxic glutamate levels. Iodine is primarily found in seawater in very small quantities and solid rocks (usually near the ocean) that form when seawater evaporates. Iodine can also be found in seafood like halibut, salmon and shellfish and seaweeds like kelp, dulse, nori and hijiki. In fact, seaweed is one of the most abundant sources of iodine because seaweed has the ability to concentrate a large amount of iodine from the ocean water.  Seaweeds and seafood should be taken twice a week from low mercury sources.
  • Kitchen Spices:  There is often a loss of taste or smell with PD, and the use of strong spices like thyme, oregano, rosemary, ginger, tulsi (holy basil which is sharper than regular basil), cardamon and star anise are not only strong antioxidants but have penetrating flavor and can enhance cerebral circulation.  Do not forget that people with impaired taste can often perceive sour flavors like lemon juice, and vinegar or salty tastes (use seaweed granules, Celtic sea salt, Himalayan salt, iodized sea salt but no MSG.)  But turmeric is the king of anti-inflammatory spices.  Turmeric is an adaptogen that is strongly antioxidant and anti-inflammatory, which crosses the blood brain barrier and is neuroprotective. It is considered a panacea herb in Ayurvedic medicine. It is used in curries, soups, smoothies and in milk.  My favorite way to take medicinal doses is to take 10 oz. dried turmeric, 1/2 ounce freshly ground black pepper and 1/2 oz. ground ginger and mix well.  Then stir in a local honey until it has the texture of cookie dough.  Take a heaping teaspoon once or twice a day.
  • Good fats and oils:  Most seed oils or conventional cooking oils are too high in Omega 6 fatty acids at a time when the Omega 6/Omega 3 fatty acid ratio (PUFA) has gone from 2/1 to 30/1 today.  I recommend avoiding seed oils in favor of fruit oils like coconut oil and olive oil.  For cooking you need a more saturated oil like coconut oil that will not peroxidize (go rancid).  Ghee or animal drippings from grass-fed organic animals won’t distort under heat either compared to other oils.  For raw consumption, avocado, olive oil, black seed oil (see below) and lemon flavored fish oil are useful.  Coconut oil with its ketones has, according to case histories, caused a reversal of Alzheimer’s dementia so is worth considering for the cognitive decline of Parkinson’s or Lewy’s dementia.  It also offers protection from viral diseases.  1-3 tablespoons in oatmeal or other food.  It is being sold as an expensive functional food for Alzheimer’s.
Fresh Turmeric Root
  • Seeds are something I tend to avoid because we get too many Omega 6 oils in our diet, but a few are outstanding exceptions.  Flax seed, hemp seed, black seed and black sesame seeds all help nourish the bowel and help stop constipation, but each has specific virtues.  Flax seed has Omega 3 fats that some people can, through genetics and good lifestyle, convert to DHA and EPA.  You need to grind it to get the Omega 3s but the lignins in the skin do have some laxative benefit if you don’t. It goes rancid very fast and I recommend getting a coffee grinder and grinding immediately before eating.  It is good in oatmeal, over salads, in yogurt and preground in smoothies.  Hemp seed is currently either steamed or shelled  in the US so that it cannot grow.  It is a good source of Omega 3s but can also go rancid easily.  I prefer to make hemp milk or to use it in smoothies.  Black sesame seed (He zhi ma) tonifies both Liver and Kidney yin, nourishes blood and secures Essence. Black sesame seeds are very rich in iron, magnesium, manganese and copper. There are about 90 mg of calcium in one tablespoon of unhulled (black) seeds It is used in both food and medicine, especially for women and the elderly but since Parkinson’s patients of both sexes are often Blood deficient, don’t let tradition stop you.  Black seed (Nigella, black cumin) is used widely in the Middle East, as seed or oil.  It smells something like thyme and facilitates a healthy inflammatory response including cell signaling chemicals and hormone-like messengers.  Small amounts are put in string cheese and pickled Moroccan lemons, over salads, in pilaf or it is used medicinally.  According to Mahfouz and El-Dakhakhny:

Ladybug on Fava bean flower

“Two of the most volatile oils found in Black seed are nigellone and thymoquinone which were fist discovered in the herb in 1985. Nigellone offers both anti-spasmodic and bronchodilating properties which contribute to Black Seed’s potency against respiratory ailments. It also acts as an antihistamine which helps to reduce the negative symptoms of allergy sufferers. Thymoquinone contains excellent anti-inflammatory and analgesic properties. It is also a strong anti-oxidant and helps cleanse the body of toxins. Both nigellone and thymoquinone work in conjunction with one another to enhance Black Seed’s action against respiratory ailments. It also provides a healthy alternative to the more commonly prescribed cortisone based therapies used by allergy sufferers. Black seed provides a rich supply of polyunsaturated fatty acids. These ingredients play a key role in daily health and wellness. They help to regulate the metabolism, carry toxins to the skin’s surface for elimination, balance insulin levels, regulate cholesterol, improve body circulation, and promote healthy liver function. A deficiency in polyunsaturated fatty acids can lead to a wide number of health problems including nervous system disorders, uninhibited growths, and skin diseases. Black seed contains over 100 valuable nutrients. It is comprised of approximately 21% protein, 38% carbohydrates, and 35% plant fats and oils. The active ingredients of black seed are nigellone, thymoquinone, and fixed oils. Black seed also contains significant proportions of protein, carbohydrates and essential fatty acids. Other ingredients include linoleic acid, oleic acid, calcium, potassium, iron, zinc, magnesium, selenium, vitamin A, vitamin B, vitamin B2, niacin, and vitamin C.”

To summarize, you should get 7.5-8 servings of vegetables per day including at least 2 cooked cruciferous vegetables and the majority from the yin-tonifying list. Choose colored vegetables like butternut squash or cooked carrots for at least one serving.  At least one serving should be fermented to provide probiotic organisms (sauerkraut, kimchee) and twice a week sea vegetables (seaweeds). One serving of berries or tart cherries a day and one-half to one serving of other fruit.  Wild salmon or other fatty fish twice a week. Liver once a week. Organic pasture-raised meat, preferably organ meat on other days.  Beans especially black beans several times a week.  One ounce of tree nuts or nut butter daily. Organic eggs, preferably with a raw yolk daily. Spice your food with strong herbs, turmeric and ginger.  Sprinkle in flax seed, black seed, black sesame or hemp seed daily.  Two to four cups of coffee, two liters of water and two cups of other beverages.

Also see Kathrynne Holden‘s book on nutrition for people with Parkinson’s, Eat Well, Stay Well with Parkinson’s Disease which is available through Amazon or for download here.  While  she has somewhat more conventional food choices than make it through my Chinese medicine/herbalist lens, she has worked with PD for many years, has special expertise about food/medicine interactions and has dealt with malnourished people with Parkinson’s in both hospital and clinical settings.

I would be remiss if I did not mention Dr. Terry Wahls who suffers from MS but found a way of eating that took her from a tilt-recline wheelchair to riding horses and freely biking today.  She eats a variation on a paleo diet that is primarily vegetable based, specifically designed to support the brain and mitochondria. This is especially important for people with Parkinson’s, ALS, Huntington’s, PTSD, migraines, dementia and MS.  The vast majority of people do not eat to support life and need some significant changes. I urge you to take the time to watch her TED Talk.  If you want more, she has a video class on nutrition and the brain :

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