Tag Archives: health

DEFENDING HERBALISM, OR NOT

Traci Piccard
Traci Piccard

This is a guest post by Traci Piccard at Fellow Workers Farm Apothecary and I thought it was so right on point that I wanted to share it with you:

DEFENDING HERBALISM, OR NOT
At one point in my herbalist journey I refused to read or listen to anything which criticized my path. Those jerks! What is their problem? Herbs are great! Haven’t they read my blog?!?!?! And then I sought these people out, just to get mysef.

My love of herbal medicines was fragile, like a precious bit of fine China, something I needed to protect and guard. And I felt like I needed to defend my right to use herbs and to make my own health choices, and I was interested in being right.

I would pick out the one point that they got wrong, while ignoring the parts which may have taught me something. Why can’t everyone see my way?!?! How can they possibly not GET this!?!?

But now, I don’t give a rat’s ass.

I have moved through the idea that other people need to believe what I believe. (Mostly.) I actively seek out people who don’t use herbs, and I am interested in why some people dislike them, make other choices or can’t access them.

I have tried things. like actually tried, not just read about them in a book or a magazine.

I have seen examples where herbs and other “alternative” healthcare have not worked, are not the best choice, or are promoted in actively manipulative, confusing or even potentially harmful ways.

And ultimately, I feel less threatened by others who want to prove me wrong. Go ahead. In fact, it would be helpful. I will read your critiques now, and sometimes they are right, sometimes wrong, sometimes both. I feel more confident in my use of plant medicines and my connection with plants, as well as my movement and nutrition choices, but I am always willing to learn more, to dig deeper, to ask questions, even of myself.

And I can see the humor in our humanity, the way we divide ourselves, the way we all form our groups and our paradigms and our dogmas and stick onto them like medicinal leeches. I am this and you are that. It is freeing to unstick myself from the sweaty leg of any one side, any one path.

And as I get older I have more of a grasp of what it means for a person and an idea to mature. I do love the new, fresh, youthful rage-against-the-system energy that innovates and wears hot pink and turns it up and boinks everything that moves, and must yell THIS WORKS in all caps on every herbal forum. Juicy, but fragile. Now I am falling in love with this more mature phase that brushes off others’ hyperbole and panic, lets my actions speak for themselves and commits to just keep walking, outlasting the haters. Well, tries to.

I still want to debate people who disagree with me, respectfully, and I still want to share my love and joy around plant medicines. And, OK, I occasionally still craft long silly arguments in my head. But I am not afraid of the other opinions and approaches anymore. And there are many sides, not just 2, not just for vs against, not just pro vs anti, not just woo vs science, not just tin foil hats vs Big Pharma conspiracies. Maybe, sometimes, they have a point. Or maybe they are reactionary douchebags. Maybe they are just lonely or disconnected, and maybe we can be friends.

Perhaps now I’m strong enough to find out.

Traci_4210

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Six Month Update on the Stem Cells

Diseases and conditions where stem cell treatm...
Diseases and conditions where stem cell treatment is promising or emerging. Bone marrow transplantation is, as of 2009, the only established use of stem cells.                                                 (Photo credit: Wikipedia)

As many of you know I had a stem cell implant in January at StemGenex in La Jolla California.  I had been somewhat discouraged by the effect on my Parkinson’s disease but two different people in the past week have spontaneously remarked that my tremors have reduced. The tremors have spread to the other side, but are less intense.  So it may well be that I am not the best judge- I only pay attention when the tremors are active.

I want to say right off that even if I’d had no effects whatsoever from the stem cell implant that valuable information would be derived from the study.  We need to learn who responds and who does not.  There are considerations of the effects on insulin resistance and gut bacteria, as well as vagus nerve stimulation that affect the success of stem cell implants. We need more experimentation on how and where to administer the cells and what activities will impact their proliferation.  (Too bad for nonresponding participants who pay out of pocket but good for science.)

It is true that I haven’t had the dramatic changes that I expected. And I might have done better with stem cells taken from the cord blood of a newborn rather than my own adipose (fat) cells. When you are fat, the fat cells can be hypoxic and less vital. One doctor I spoke with in Mexico said he prefers cord blood because the stem cells are more active, even if there are considerably fewer of them.  If you are heavy and are considering stem cell implants you might consider using cord blood.  Cord blood is not available in the US, but there are reputable firms outside of the country.

Do I think losing weight prior to a stem cell implant might have helped?  Only with a few years lead time and lots of detoxification.  The problem is that fat stores toxins to protect the body from the harm they can cause.  I have tested high for lead, strontium, DDE and other endocrine-disrupting compounds. Weight loss can dump toxins into the blood stream and tissues as fat cells are broken down or deflated, which is why I have gotten sick every single time I lost weight, even slowly.  I did a course of herbal detox  and DMPS, EDTA, and Olestra (1) chelation prior to the stem cell implant to reduce toxins but stopped a month before the implant to let my body normalize.  Chelation cannot be done after the implant until the cells have finished multiplying.

A friend tells me that our neighbor is still experiencing improvements 2 years after his stem cell implant – and it took a while to build up.  He saw the greatest improvement after he started getting deep massage and using a vibration platform late in the first year. So there is still hope. It has been only 6 months. One woman with MS who was going through the implant with me for the third time said that the first time there was no change until 6 months and suddenly she was able to raise her legs two feet instead of two inches.  Pazienza, Karen!

Confidence Fitness Vibration Platform. http://amzn.to/1Ge8Ifw
Confidence Fitness Vibration Platform. At http://amzn.to/1Ge8Ifw

I was advised by a colleague with Parkinson’s to get a vibration platform to increase the stem cell activation and to reduce Parkinson’s symptoms. I used one last week while visiting my parents and it definitely activates qi and blood, affecting not only circulation but eliciting a strong stretch-reflex contraction in muscle fibers.  It is a very efficient anaerobic form of resistance training and they claim that 10 minutes of platform exercise is like 60 minutes of regular exercise.  Vibration platforms for the home run between $200- $6000.  While the pure platforms without handholds look like they give a stronger vibration and certainly fit better in a NYC apartment, the design looks risky for someone with Parkinson’s.  The $250 Confidence Fitness machine has over 700 five star reviews on Amazon.  I am saving up for it now.

Handhold- less dual motor vibration plate (what do you do with the remote while shaking?
Handhold- less dual motor vibration plate (what do you do with the remote while shaking?)
  1. Ronald J. Jandacek, James E. Heubi, Donna D. Buckley, Jane C. Khoury, Wayman E. Turner, Andreas Sjödin, James R. Olson, Christie Shelton, Kim Helms, Tina D. Bailey, Shirley Carter, Patrick Tso, Marian Pavuk.Reduction of the body burden of PCBs and DDE by dietary intervention in a randomized trial. The Journal of Nutritional Biochemistry, 2014; 25 (4): 483 DOI: 10.1016/j.jnutbio.2014.01.002

 

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Herbal Formulas in Common Use

Liu wei di huang wan
Liu wei di huang wan is a traditional formula made from raw herbs or from many manufacturers (Photo credit: SuperFantastic)

‘In Chinese medicine there are hundreds of traditional formulas that belong to the commons. If you buy Liu wei di huang wan (Rhemannia 6) or Bu zhong yi qi tang (Tonify the Middle and Augment the Qi Decoction) you will find essentially the same formula made by a wide variety of manufacturers under the same name. They may have minor variations but are essentially the same in function and content.Many of the recipes and their names derive from famous doctors like Zhang Zhongjing who wrote the Shan Han Lun or Sun Si Miao. The names of the formulas neither are nor can be trademarked by a single company.  The Bensky formulas book contains over 500 traditional formulas.

There exist in Chinese medicine private, patent-protected formulas like the famous Yunnan Bai Yao stop bleeding formula.     The difference is that Yunnan Bai Yao is relatively modern, developed by  Dr. Qu Huan Zhang in 1902, was always private (but now controlled by the Chinese government) whereas other traditional formulas are and have been public for centuries. So no one can trademark “Liu wei di huang wan”, although one can create other similar formulas for yin deficiency. There certainly are other formulas to stop bleeding and many of them use san qi (notoginseng root) which is believed to be the basis of Yunnan Bai Yao’s secret formula but they cannot use the non-traditional trademarked name.

Yunnan Baiyao
Yunnan Baiyao a protected Chinese herbal formula

There are also many modern “hospital formulas” whose exact content remains sketchy in Medscape abstracts and these are being protected for profit.  In addition many companies make patent-protected variants of traditional formulas under other names, but the vast majority of herbal formulas are traditional. In Japan these formulas with regulated recipes are part of the the National Health Insurance drug registry.

We have traditional recipes in Western herbal medicine too although far fewer of them.  Mithridaticum was a shotgun anti-poison remedy from the first century BCE,.  The Romans enlarged and adapted it as “Theriacum”, described in pharmacopoeias for centuries up through the European Renaissance.  The Middle Ages brought Thieves’ vinegar, allegedly composed by the midwife mother of one of a gang of 4 thieves who managed to steal from houses where the Black Death had stricken without themselves contracting the plague. During many centuries great herbalists from Hildegard of Bingam to Gerard to Maimonides to  Culpepper used formulas, but few were standardized.  Most  Western herbals classified single herbs both by properties and energetics even if they might be used in combined formula. And assaults against using herbal medicine, from early Christian faith-healing through the witch trials up to the early 20th century Carnegie Commission broke the continuity of traditional herbal formulas in a way that the documented Chinese herbal tradition did not have to contend with.

There were a number of well-known formulas in the 19th and 20th century  Samuel Thompson came up with his famous Composition Formula which treated diarrhea and dysentery along with a variety of formulas featuring cayenne and lobelia. Roberts Formula is traditional for ulcers.  Neutralizing cordial was developed by the Eclectics for fermenting and irritating conditions of the stomach and intestine.  Mother’s cordial was an Eclectic formula promoted by Feltzer and Lloyd to prepare the uterus for labor at the end of pregnancy.  Antispasmodic Tincture made from lobelia seed, crushed skullcap, skunk cabbage root, gum myrrh, black cohosh and cayenne  was developed by Thompson and refined by both Dr. Christopher and Jethro Kloss for spasms of all kinds and lung conditions. Kloss, D. Schulz, Tommie Bass, Hannah Kroeger, Dr. Shook and Dr. Christopher popularized a variety of  formulas for the public good including Blood Stream Formula for clearing “bad blood”, Bone Flesh and Cartilage (BF&C), Anti- Gas Formula and many others. These were freely adapted and many companies produce versions of the formulas.  Other herbalists who drew on common formulas include Harry Hoxsey whose named formula drew heavily on the Park Davis Trifolium (red clover) Formula.  Black salves and drawing salves for cancer also percolated through the herbal commons, as did versions of Essiac.

Lydia Pinkham's Herb Medicine (circa 1875) rem...
Lydia Pinkham’s Herb Medicine (circa 1875) a proprietary herbal patent medicine still under trademark

There were also trademarked names and patented products.  Swedish Bitters is a trademarked version of digestive bitters There are licensed and trademarked Edgar Cayce formulas.  Lydia Pinkham tonic is trademarked.  Airborne is a modern trademarked and patented product derived from the traditional Yin Qiao San with additional nutrients and echinacea. The difference between a trademark and a patent is that a trademark restricts the name of the formula but not the content while the patent restricts both.

Rosemary Gladstar was one of the early pioneers of the current wave of American herbalists and started teaching in the 1970s.  In the tradition of the earlier herbalists she did not trademark her formulas and a wide variety of products have been inspired from her teachings, often using the same names.  Fire Cider is a term invented by Rosemary Gladstar over 35 years ago, and has been shared by her freely since then to tens of thousands of people. She has it in her published and copyrighted books and teaching handouts from the 90‘s and pamphlets from the 1970’s. The formula is much older than her – indeed Mrs. Grieve has a similar formula under another name and countless middle European grandmothers have made horseradish and onion-based therapeutic vinegars.  Various people have used both the name and basic formula for decades.  Monica Rude of Desert Woman Botanicals has sold Fire Cider since the 1990s, for instance and taught the recipe under that name.

Fire Cider by UberHerbal
Fire Cider by UberHerbal

We have an herbal incident occasioned by a firm named Shire City who decided to trademark the term “Fire Cider” based on inaccurate information provided to the US Patent and Trademark Office.  One of the principals of the firm apparently studied herbalism at the school where Monica Rude was teaching about Fire Cider and experimented with making fire cider at that time. The Shire City  Trademark application summarized here claimed that the  the first use of the term was 12/4/2010 and that date was its first use in commerce.

A simple time delimited Google search would have uncovered Fire Cider for sale listings before 2010 like this one .

  • Susun Weed had a Fire Cider forum topic on Fire Cider in 2003.
  • Amanda McQuade made a video on it in 2009.
  • Food.com listed the recipe in 2005.
  • The current Desert Woman Botanicals sales page is dated March 15, 2005 and Rootwork Herbals sold it in 2008.
  • A 2005 article on the Desert Woman Botanicals web site discusses selling Fire Cider in Massachusetts, Utah, Texas and Arizona as well as New Mexico.
  • A 2002 Etsy page listed several Fire Cider variations by different sellers. (All dates according to Google.)
  • GreenMedInfo discussed it in a Joe Cross interview on February 1, 2001.
  • Rosemary  Gladstar of course has it in her copyrighted books and teaching materials at least since the early 1980s and perhaps earlier. And on Rosemary’s Fire Cider YouTube video.
  • Rosemary is credited with inventing the term and bringing the basic recipe to the herbal community in her books, The Home Medicine Chest (Storey Publications, 1999) and Rosemary Gladstar’s Family Herbal (Storey Publications, 2001)  and has expressed her desire that the term remain in the herbal commons.

We do not know whether the erroneous information in the trademark application is accidental, due to the ineptitude of their attorney (who apparently didn’t do a Google search) or was deliberate, done with the specter of future work defending the trademark, or was done with the cooperation of Shire City.  What we do know is that someone from the company or their counsel contacted Etsy and Amazon and that a number of small herbalists were shut down . They insisted on their right to trademark the name, describing its use as unknown before they publicized it. Given the patently untrue assertions, the high regard Rosemary Gladstar is held in and the history of fire ciders, the herbal community erupted with petitions that picked up thousands of signatures in a few hours, calls for boycotts and the Shire City Fire Cider Facebook page was flooded with critical comments.

fire cider fixins
Fire Cider Fixins’ from http://www.fareisle.com/blog/2014/2/2/world-fire-cider-day for World Fire Cider Da

After requesting a few weeks to consider what to do they doubled down and essentially claimed that the only thing to be done is to sue them, “The only thing that will make the name ‘fire cider’ a generic term is a ruling from the USTPO. Challenging a trademark through the USTPO is a commonplace occurrence with clear rules and requirements, and we welcome anyone who would like to avail themselves of this path. This is legal, fair, and something to be expected as a part of doing business.” Now it isn’t their only option and they may be trading on the idea that the herbal community is unable to mount a legal challenge.  The trademark can be withdrawn or abandoned , as was “Soap Loaf”  or “Lotion Bar.”   It could be transferred to Rosemary Gladstar who would allow free use or it could be amended to exclude “Fire Cider” as “Cider” was also excluded but to protect a name like “Dana’s Fire Cider” or “Shire Fire Cider.

To summarize, Fire Cider has been part of public domain for decades, not a brand name and not even one that was trademarked by its inventor.  It is traditional like Bu zhong yi qi tang rather than proprietary like Yunnan Baiyao.  Analogously one could legitimately trademark “Shire Fire Cider” which is not a common name. But it was improper to trademark “Fire Cider” because that term was generic in the trade, just as the traditional Chinese herbal formulas like Lu wei di huang wan are.

There is currently a boycott of Shire City’s Fire Cider and it looks like there may have to be a lawsuit.  People are asking local health food stores and other venues not to carry the product until the trademark is resolved.  So speak to your local health food, food store or co-op and :

Rosemary Gladstar by : Jason Houston
Rosemary Gladstar by : Jason Houston

 

 

 

 

 

 

 

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Dealing with Constipation

constipation
Constipation

Constipation refers to bowel movements that either occur less often than expected or with a stool that is hard, dry and difficult to pass.  (Types 1-3 on the Bristol Stool Chart, below.)  A healthy adult should pass one to two stools a day, although some otherwise healthy adults pass a stool every other day.  There are a number of reasons one might not pass feces, including diet, fluid intake, medications, stress, anal pain from hemorrhoids  or fissures, lack of probiotic gut bacteria, laxative abuse, specific diseases, such as stroke, diabetes, thyroid disease and Parkinson’s, change in circardian rhythm (due to irregular sleeping while traveling) and a poor posture while eliminating

In Chinese medicine proper digestion has been seen as a paramount hallmark of health and one school of medicine considered poor digestion to be the root of almost all diseases. Chinese medicine looks at whether the constipation is because of a dry hard stool (dryness, usually due to heat) or a normal stool without peristalsis (qi stagnation).  Heat can be of  external or internal origin and is the major cause of constipation, especially if stools are hard or dry. Qi stagnation involves anything that blocks peristalsis, from emotions (Liver qi stagnation) to physical blockages  or lack of exercise.

Laxatives and Laxative Abuse

Western medicine  recognizes two types of laxatives:  hyperosmolar and stimulant.  The hyperosmolar laxatives (MiraLax, GoLytely, and Philips Milk of Magnesium) are agents that draw water into the bowel, making the stool softer and promoting movement of the stool.  Hyperosmolar laxatives are over the counter medications, often used in healthcare as they have few risks and tend not to cause abdominal cramping.  Stimulant laxatives, on the other hand, stimulate the propelling action of the bowel..  These include the anthraquinone laxatives  These medications are associated with cramping and potentially harmful side effects.

Kyle Thompson, self made. Stool images and tex...
Kyle Thompson, self made. Stool images and text made into document in OpenOffice.org, exported to PDF and then captured in OS X as a roundabout, but best way of ensuring good layout! Intended for use in a new article Bristol Stool Chart (Photo credit: Wikipedia)

In Chinese medicine we use three classes of laxatives.  Emergency cathartics  are given only in serious circumstances such as constipation accompanied by ascites.  Only experienced practitioners should use this category which causes serious cramping and diarrhea. Strong laxatives like Da Chen Qi Tang are often based on stimulants like rhubarb root and hyperosmolar magnesium, which are only taken until the first bowel movement. The second category is comparable to the anthraquinone laxatives (like senna, cascara sagrada, buckthorn, or aloe), Mirelax, phenolphthalein and bisacodyl.  Gentle bulk laxatives make up most treatments for constipation. The gentle bulk laxatives include flax and psyllium seed (Metamucil), methylcellulose (Citrucel) and prunes.  Stool softeners (emollient laxatives like docusate) are more benign western laxatives which are similarly gentle and allow fluids to penetrate the hard stool. Stool softeners are commonly used when there is a need to soften the stool temporarily and make defecation easier (for example, after surgery, childbirth, or heart attacks). They are also used for individuals with hemorrhoids or anal fissures.They have temporary uses,  but over the long run water in the diet should do the trick for most people.

A unique forth class of nourishing laxatives comes from Ayurvedic medicine and is based on the rasayana (longevity tonic) Triphala which consists of three fruits: : Amala  (Emblica officinalis) one of the highest natural sources of Vitamin C, Bibhitaki (Terminalia bellirica), and Haritaki (Terminalia chebula).  This is the only nourishing laxative I know of and can be used to recover peristalsis after damage from overuse of anthraquinone laxatives.  It may be combined with other herbs like guggulu,

Laxative abuse can be a major cause of constipation since people with constipation will often inappropriately choose stimulant laxatives, use them too frequently or use them for purging in a misguided attempt to control weight.  This can take over the body’s natural peristalsis and  the person will no longer be able to have a normal bowel movement. The anthraquinonne laxatives will cause laxative dependence within two weeks of constant use. Herbalist David Hoffman tells how the British Navy in its wisdom wanted its sailors to be regular, so issued a daily dose of senna, dooming the sailors to lifetime laxative dependence.  (Perhaps if they had listened to the Indians they were colonizing, they might have learned to overcome the dependence with triphala!)

Medications and Constipation

There are a number of medications that can cause constipation, notably pain killers and other medicines based on opiods.  I once treated a woman on methadone maintenance who had retained so much stool that she appeared 9 months pregnant.  She spent a large part of each day trying enemas and other actions to move a little stool.  The opiate killed her peristalsis.  Codeine based pain killers are known for causing constipation that can be worse than the pain being treated.  Examples include Tylenol #3, oxycodone (Percocet), and hydromorphone (Dilaudid.)  Ibuprofen (Motrin) often works as well after the first few doses of codeine.

Diuretics like Lasix and calcium channel blocking drugs such as diltiazem (Cardizem) and nifedipine (Procardia) can dry the stool out. Antidepressants such as amitriptyline (Elavil, Endep) and imipramine (Tofranil and anticonvulsants such as phenytoin (Dilantin) and carbamazepine (Tegretol)  are constipating although Prozac is not. Parkinson’s disease medications including anticholinergic medications, Artane and Cogentin can constipate, but then so can the disease.  Even iron supplements and aluminum-containing antacids such as Amphojel, Maalox, Mylanta, Gelusil and Rollaids can cause constipation.  Speak to your doctor about non-constipating alternatives and consider natural alternatives to iron and antacid supplements.  For instance dock (Rumex crispus) tincture helps iron assimilation in drop doses. And bitters before meals can reduce the need for antacids (which are usually the wrong remedy for people over 30.)

Diet and Constipation

Diet is perhaps the main cause of constipation and can be the easiest to remedy once laxative dependence is addressed.  Dietary influences come from a variety of sources. For example magnesium  has decreased by over a third in most foods tested by the USDA since the mid 1970s and magnesium helps attract fluid into the stool.  But we also have less fiber and fewer bitter vegetables, both of which would help reduce constipation..

  • Honey Rum Fruit Salad
    Honey Rum Fruit Salad (Photo credit: SliceOfChic)

    Fluids:  If you don’t get enough fluids from food or drink, your constipation won’t go away. You need 6-8 servings of fluid a day, approximately 2 liters.  It does not have to be from pure water although water is good.  Fluid can come from drinks, fruit like watermelon, vegetables like cucumber, coffee and tea (although a small amount of caffeinated beverages will pass through without hydrating you.) If you sip- half a cup or less at a time- you will hydrate better.  If you gulp, you will trigger your urinary reflex.   That is a good thing because it flushes out the tissues but you need hydration to stop constipation.

  • Lots of fluid-rich fruits and vegetables like watermelon, honeydew melon, cucumber and celery.
  • Allergens or food sensitivities, especially milk can cause chronic constipation by creating inflammation that causes changes in the lining of the gut, specifically the  eosinophilia of the rectal mucosa. (see references below.) Sometimes this causes diarrhea or mixed constipation and diarrhiea, but constipation alone can be triggered.
  • Insufficient fats.  Fats lubricate the intestines and allow for smooth passage of the feces.  In Chinese medicine we use oily seeds like apricot pits, flaxseed, cannabis seed and olive seed.  Coconut or olive oil also work.
  • Fiber: You need about 25  to 30 grams of fiber every day to soften the stool and encourage proper bowel function. Most American diets contain less than half that amount. Fiber from powdered supplements can impact if you don’t take them with enough fluid. Fruits and vegetables provide fiber in a hydrating package.  Bananas, apples, celery, fennel root and cucumber all help.
  • Mucilage is a specific kind of water-soluble fiber that provides lubrication.  Sea vegetables, mucilage from slippery elm bark, hibiscus flowers, marshmallow root, okra, chia seeds or flax seeds will also lubricate the intestines.
  • Lack of bitters. The bitter taste stimulates the liver to make bile and to stimulate both digestive juices in the stomach and peristalsis.  We have significantly reduced this important digestive signal by hybridizing bitter fruits and greens to have a sweeter taste.  Bite into a lime peel, then squeeze the sour juice into water and drink it before your meal.  Or eat grapefruit, radicchio salad, Karela (bitter melon), drink black coffee or have a little Angostura bitters in water before your main course.  Urban Moonshine makes purse-sized bitter sprays that make it easy to get the bitter trigger in the go (tiny amounts work.)
  • Coffee.  This is one of the most common agents to stimulate the bowel and a cup in the morning is often followed by a bowel movement.  Coffee is a bitter, is rich in magnesium,  chlorogenic acids, cafestol, kahweol, caffeine, theophylline and theobromine.
  • Fermented foods: are a source of probiotics wrapped up in fluid, frequently fat and often fiber.  Aside from buttermilk, yogurt, kefir, sour cream, fermented butter, live blue cheese, gorgonzola, kombucha and live vinegar, which don’t appreciably contain fiber with their organisms,  pickles, kim chee, sauerkraut, fermented veggies, olives, miso and fermented fish all help repopulate the gut and move things along.  The fermented vegetables are easy to make if not found nearby, and they contain prebiotic foods for the probiotic organisms.  Te good bacteria form a living wallpaper in your gut and help the health of the intestinal villi.
  • Probiotic supplements can be useful to repopulate the gut after antibiotics but very few probiotics have much more than 4-5 Lactobacillus or Bifidobacteria species and we have hundreds to thousands of naturally-occurring gut species.  So while there is value in populating the most common probiotic species there is a need to take in probiotic foods.   The two probiotics I recommend are Pharmax Sinbiotics Human Lactobacillus Complex  which come with very potent sachets and Florastor which uses the less common probiotic yeast Saccharomyces boulardii.  In Europe one can find probiotic strains of benign e-coli (the kind thin people have naturally) like Escherichia coli Nissle, but the FDA does not permit their sale in the USA.
  • Vitamin C is also laxative in large doses.  1000 mg of the vitamin in the morning can help stimulate a bowel movement.

Physical Aspects of Constipation

The Puborectalis Muscle kinks the rectum closed while sitting but relaxes while squatting.

First, movement is necessary to provide qi to the bowels so peristalsis can occur.  A person who never moves is likely to have trouble moving their bowels.  Engaging in walking after meals is good for someone who is beginning to move.

Acupuncture can also help move the bowels.  Your acupuncturist might us points near your belly button, with additional points on your lower leg to moisten the stool and points below your knee for peristalsis.  The acupuncture acts as a reset button for your body to take over normal elimination.

But another, less-appreciated issue in western society is that we eliminate in the wrong position. For most of human history and in most places people have defecated in a squatting position. With the knees above the hips and the pelvic floor engaged, elimination is easier and more complete.  I did not appreciate this until going to Beijing and getting intestinal problems.  We stayed in a fine hotel that provided both western thrones and eastern squat toilets and surprisingly it was easier to manage with the eastern toilets because you could clear out more easily.

More significant to constipation is the understanding of the role of the puborectalis muscle. The large intestine unloads at the rectum.  However the rectum is supported by a loop of muscle, the puborectalis muscle which in a sitting or standing position chokes off the rectum to maintain continence. When one squats, the anorectal angle is increased, the rectum straightens and the stool can be easily evacuated.  We pay a high price for retaining the Victorian “throne”. Because the anorectal angle is in a kinked position while sitting one is forced to strain in order to move the bowels, which is the main cause of hemorrhoids. While squatting the angle straightens out allowing the fecal matter to eliminate quickly and easily without straining.

Since most of us will be unable to install a squat toilet in a western home or business, the Squatty Potty was designed as a corrective to the toilet. It consists of an elevated step stool that has a cutout to hug the toilet and allows elimination with a 35 degree anorectal angle.  It is better  than using a narrow foot stool and certainly better than standing on an unstable toilet seat.

Sitting with elevated feet is not quite as efficient as eliminating in a true squatting position. Weight rests on the buttocks instead of the feet, although one probably could work up to a true squat on the wood  versions, as seen in the second video below.  Nonetheless it is better than sitting at either a 90 degree angle or balancing on an unstable toilet seat.

Sources:
The Role of Interstitial Cells of Cajal (ICC)in Gastrointestinal Motility Disorders –What the Gastroenterologist Has to Know Christian Breuer.Clinic of General Pediatrics,Department of Pediatric Gastroenterology,University Children’s Hospital Hamburg-Eppendorf,Germany

Chronic Constipation and Food Hypersensitivity – An Intriguing Relationship. A. Carroccio, G. Iacono. Aliment Pharmacol Ther. 2006;24(9):1295-1304

Multiple food hypersensitivity as a cause of refractory chronic constipation in adults. ANTONIO CARROCCIO, LIDIA DI PRIMA, GIUSEPPE IACONO, ADA M. FLORENA, FRANCESCO D’ARPA, CARMELO SCIUME` , ANGELO B. CEFALU`, DAVIDE NOTO & MAURIZIO R. AVERNA. Scandinavian Journal of Gastroenterology, 2006; 41: 498/504.

Health Benefits of the Natural Squatting Position by JONATHAN ISBIT

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Why you should taste your herbs

English: tea drinking
Tasting while tea drinking (Photo credit: Wikipedia)

Anyone who consults with me knows that I always suggest taking herbs in a way that allows you to taste them.  That means that I usually use teas, tinctures, syrups, herbal jams like chayawanprash or turmeric honey, pickled herbs, overnight infusions, herbal decoctions or powdered herbal extracts that are added to water.  The only time I really approve of using capsules is when giving the severely bitter anti-parasite herbs (usually a long term proposition and the bitterness is for the parasite) or when a person is so debilitated that they will miss dosages unless they have pills to tide them over until they can brew up their herbs.  In that case I may give herbs in two or more forms.

Why would you want to taste your herbs?

Taste is not just an aesthetic sense.  It provides the body with information that the herbs are coming and to get ready to use them.  It  triggers secretions, hormones and digestive processes. All things being equal, a dose of herbs that are tasted will be assimilated faster and put to work earlier and may be as effective at lower doses which can reduce potential side effects.

Taste can be protective. Any woman who has been pregnant knows that taste and smell can direct you away  from foods that can potentially upset the baby.  I will only give herbs in a form she can taste because revulsion means she should not take that herb.  Similarly taste can regulate dosage.  I like to nibble on aromatic but potentially toxic fresh sassafras leaves but at a certain point my body suddenly says, “Stop!”

The entire digestive tract has taste buds, as do the lungs.  Yes, taste buds. Potentially you could taste your herbs in your small intestine when the gel caps break down, but that would mean signals to the stomach, liver and gallbladder would be missed. The bitter taste, for instance, triggers the secretion of HCl in the stomach and bile through the liver and gallbladder.  Bile triggers peristalsis in the gut and potentially reduces depression since most neurotransmitters like serotonin are made in the gut.  The sequence is set up for a reason and we shouldn’t short circuit it.

There are lymph glands in the tongue and throat. That means if you take your echinacea tincture it gets into your lymphatic system immediately instead of being digested and going through circulation.  Faster, and probably needed in lower doses than with capsules.

Capsules are usually made from extracts which leave minerals behind. They tend to be in tiny dosages, say 500mg of 5:1 extract instead of 9 grams per average herb as you would typically find in a Chinese formula.

TweEnglish: nty five size 0 capsules of 500mg ...
Twenty five capsules of herbs. But do you know what is in them or if it is fresh?
photo: Wikipedia commons

Capsules also can hide what is inside since at most you see a powder behind the gel cap. I can tell plantain from foxglove when I see it in leaf form, but I wouldn’t be able to tell the powders apart.  I also can’t tell what concentration is in a capsule and Consumerlab frequently finds that herbal capsules contain less material than claimed.

A recent study using a barcoded analysis found that one third  of encapsulated herbs tested contained plant material  not indicated on the label and 30/44 contained some measure of substitution. Now some of that probably includes rice flour used as an anti-clumping agent or alfalfa used as a filler, but there was a significant problem with adulteration. One reason could be that in Chinese medicine, a single herb name may refer to several functionally similar species which might be considered adulterants unless properly identified by species. But there is also ignorance and fraud in the market. ( I would also note that the analysis technique may not recognize processed herbs so could overstate the problem.)

When plant material is powdered, more surface area is exposed to the air so it can oxidize and go bad sooner.  This even occurs within capsules.  If I were to smell or taste the herb I would know if it were rancid or inert, but inside the capsule, who knows?   (This also applies to fish oil or cod liver oil.)

Teas, infusions and decoctions also have an advantage of being given in a material dose which can include minerals along with other constituents.  They are more nourishing, as are herbal jams, syrups and honeys.

Herbs are outstandingly safe and rarely cause any deaths, unlike pharmaceuticals, so there is little reason to be afraid. See my article on the barcode study here which elaborates on the safety issue. But you want your money’s worth and you don’t want to be undertreated when you are ill.  So the best way to take herbs is in a way that you can see, taste and smell.

And taking time to brew and drink your teas, decoctions and infusions means you are deliberately taking time to care for yourself!

 

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Useful Supplements for Parkinson’s Disease: Part 3

Dietary supplements, such as the vitamin B sup...
Dietary supplements, such as the vitamin B supplement show above, are typically sold in pill form. (Photo credit: Wikipedia)

This is part 3 of my series on nutrition and Parkinson’s Disease.  Part One and Part Two can be  found preceding, focusing on foods to eat or to avoid.  This section is on supplements.

While Dr. Terry  Wahls‘ experience with MS shows food to be more effective than supplements at providing nutrition for neurological diseases, there is a place for supplementation with vitamins and minerals, provided they are taken together with food to make up for deficient nutrients in our foods.  Paul Bergner researched the decline of minerals in the diet due to modern agricultural practices which have strip mined the soil and reduced food value in his book, The Healing Power of Minerals, Special Nutrients, and Trace Elements (out of print.)  Most minerals not included in the standard NPK commercial fertilizer declined between the mid 1970s and mid 1990s by 30% according to USDA data (and who knows since then), notably magnesium, calcium and iron.  Trace minerals often disappeared entirely: the boron in apples in the 1940s is  no longer present.  An apple a day in 1929 would be equivalent to nearly 30 a day today  in terms of iron.  So while nutritional supplements should not be relied upon alone, since they do not capture the full spectrum of antioxidants or special nutrients, they can fill some holes in the diet, particularly minerals which affect neurotransmitters like dopamine and serotonin.

Vitamins are made by plants from the sun so will not be deficient when first picked but can be destroyed in transport.  New hybrid fruits and vegetables often feature diminished nutrition along with their sweet milder flavors.  Lettuce has largely lost its bitterness, which means it is less effective at stimulating digestive juices, further reducing nutrient absorption.  The same goes with a variety of fruits and vegetables.

The taste of food is not merely aesthetic.  Tastes stimulate the body to prepare for nutrients.  Bitter tastes cause the secretion of hydrochloric acid (which closes the esophogeal sphincter preventing reflux)  and bile, which helps break down fats and  protein and moves the intestine.  Since 80% of serotonin and other neurotransmitters are made in the gut, stimulating digestive juices with something bitter can prevent or ameliorate depression found in Parkinson’s.  A bitters formula, biting down on lime peel, a radicchio salad or grapefruit before the meal can start digestion properly and will also regulate blood sugar which is of interest in Parkinson’s’ disease.  Bitters must be tasted to stimulate digestion, but do not require large amounts, so do not use pills or capsules. Food or tinctures work better.

It is important to eat looking at the health of the mitochondria, the energy powerhouses in cells, especially brain cells.  There are many aspects of this that warrant an article of its own.  A protein in the body called Parkin is believed to detect, and then clear out, damaged mitochondria from the cell. In PD cases associated with mutations in another protein called PINK1, however, Parkin doesn’t seem to do its job, and it’s thought that the damaged mitochondria that remains might lead to the cell death that causes the disease.  A number of supplements are chosen to benefit the mitochondria.

While the supplements below can be beneficial for most it is important to avoid a “one size fits all” approach.  People with Parkinson’s (PWP) differ significantly in their symptoms, medications and health conditions and they need to coordinate with the help of a doctor or trained pharmacist to make sure that effective treatment is not compromised.  Minimal research has been done on nutrients, and nothing can be said to be a cure.  But there are certainly supplements that can make PWP maximize their health.

Vitamins and minerals can be taken at the same time as foods while amino acids and herbs should be taken an hour before or two hours after meals.  Important supplements, vitamins and minerals include:

  • Probiotics.  Recent research shows that Parkinson’s disease affects the gut/brain axis and that when PWP have more enterobacteria the worse they get. Probiotic bacteria help outcompete enterobacteria and improve absorption of other nutrients.  I like the well-researched but often forgotten Saccharomyces bloulliardi and Pharmax’s human lactobacillis strain
  • Vitamin B Complex including NADH.  When Parkinson’s disease patients took 30 mg of vitamin B 2 three times each day over a period of six months, they had better motor capacity,( though these participants also  no longer ate red meat, according to the University of Michigan Health System.) NADH, an active type of vitamin B 3, helps with increasing the amount of dopamine in the brain.  Methyl folate is the preferred form of the B vitamin, folic acid.  Do not look for high Vitamin B complex levels as they will wash out, and too much B6 can interfere with Parkinson’s medication. Instead take a low dose  3 times a day:  30mg three times a day of a Vitamin B complex is sufficient but NADH, methyl folate and B12 may require separate supplementation.
  • Sublingual Vitamin B12, especially in the form of Methylcolbalamin, a form of bio-active B12 that is well absorbed and crosses the blood brain barrier.   This makes it suitable for brain-nerve disorders. It is the form of vitamin B12 active in the central nervous system, necessary for cell growth and replication. In some people the liver may not convert cyanocobalamin, the common supplemental form of vitamin B12, into adequate amounts of methylcobalamin needed for proper neuronal functioning. Methylcobalamin may exert its neuroprotective effects through enhanced methylation, acceleration of nerve cell growth, or its ability to maintain already healthy homocysteine levels.  1000 micrograms.
  • Fish or cod liver oil to provide 1000 mg of DHA (about 5 capsules or a teaspoon of Carlson’s lemon flavored fish oil which you can use to wash down other supplements.)  Make sure the oil is not rancid, which can be tested by smell. This reduces the inflammation that drives Parkinson’s. Blue Ice is another source of fermented fish liver oil that I recommend Vegetarian sources of Omega 3 oils like flax seed or chia must be converted to DHA, which is genetically impossible for a significant proportion of the population, is difficult for older patients and requires as much as 30 times the dose in those who can use it. There may be marine seaweed DHA.
  • Vitamin D3 should be taken by PD patients as few of them have sufficient sun unless they live south of Atlanta and are regularly out of doors without sunscreen at noon.  While most Americans are deficient in the vitamin, actually a hormone with hundreds of body functions, PD patients have even lower average levels.  In a long term prospective Finnish study participants who had the highest levels of serum vitamin D had a 67% lower risk of developing Parkinson’s than those in the lowest 25% of the group studied after 29 years.  People differ significantly in their ability to absorb Vitamin D and how fast it breaks down so optimum levels (50-100 ng/ml of  25 Hydroxy D) must be determined by blood testing.  It usually takes over 10,000 iu of the vitamin daily to budge numbers but people with many diseases need more, especially those who work indoors, are fat, elderly or  suffering from disease.  I needed 50,000 iu per day, twice the physiological dose one would get from the sun, to get to the low 50s after 10,000 iu for 6 months didn’t work.  It took 3 months to get there from the low 30s.  (I monitored high intake with quarterly blood tests.) In some PWP improvement is due to general health while PWP with certain Vitamin D receptor genotypes showed improvement in symptoms according to a small scale clinical trial, conducted by researchers at the Jikei University School of Medicine in Tokyo, where 114 people with Parkinson’s were randomly assigned to take a modest 1200 iu vitamin D supplement or a placebo during a one-year period. Those people with particular gene versions of the Vitamin D receptor called Fokl TT and Fokl CT benefited from the vitamin D supplement when compared with placebo. But those with another genotype called Fokl CC did not.  (At higher levels even those might have responded.)  Nonetheless proper Vitamin D status is essential for general health and makes everything work better.
  • CoQ10 plays an important role in the mitochondria and is also a potent antioxidant. In a multi-center trial published in 2002, patients with early PD took either a placebo or Coenzyme Q10, at 300mg to 1200mg per day. The results showed that CoQ10 was well tolerated and was safe at these doses. Over a sixteen-month period those PWPs who were on the higher dose showed slower disease progression than the others. Currently, a much larger trial (the QE3 trial) is underway to truly determine the role of CoQ10 in the treatment of PD. This trial is testing doses of 1200mg and 2400mg daily.
  • Glutathione, a compound with multiple effects on nerve cell metabolism as well as a powerful antioxidant, is of particular interest for PWPs because of studies showing its depletion in the substantia nigra (the site of major nerve cell damage in PD). Although laboratory tests are promising, it is still not clear what is the best way for PWPs to take this since oral doses are relatively ineffective unless liposomal.  Dosages and long term effects are not well determined.
  • Zinc participates in the superoxide dismutase and zinc-thioneine enzymes to reduce oxidative stress in the brain and oxidative stress is believed to reduce dopamine production. Zinc‘s role in inciting or inhibitory responses is not clear.  Like all metals it should be used conservatively.
  • Magnesium  is involved in a number of crucial bodily functions, from the creation of bone to the beating of the heart and the balance of sugar in the bloodstream, of special interest in Parkinson’s dementia.  Magnesium is a particularly crucial element for mediating the vital functions of the nervous and endocrine systems; it helps maintain normal muscle and nerve functions, reduces tremors,  keeps heart rhythm steady, supports a healthy immune system, prevents depression, and keeps bones strong. Magnesium also helps regulate blood sugar levels, promotes normal blood pressure, prevents or treats constipation. and is known to be involved in energy metabolism and protein synthesis.In addition, magnesium stimulates activity of B vitamins,assists in clotting of blood, relaxes the muscles, aids in metabolism of carbohydrates and minerals, helps the body maintain a regular heart rhythm, and plays a central role in the formation of ATP (adenosine triphosphate), the mitochondrial-derived fuel on which the brain (and body) runs.  Magnesium balances out the potentially toxic increased levels of calcium in the cytosol.  The forms used should be chelated (end in “ate” like citrate or orotate) but there is a lot of individuality on which forms are good and switching can be done if one form doesn’t work.  Magnesium theronate crosses the blood brain barrier but is expensive so I combine.  I generally suggest 800 mg of magnesium citrate to start.  Topical magnesium chloride also  known as magnesium oil can be applied twice a day when diarrhea from oral magnesium  is a problem.  Most Americans are deficient in magnesium.
  • Iron can calm  some spasms if deficient, but must be used with care in Parkinson’s.  Iron is accumulated in different brain regions in presence of neuropathologies and increased levels of iron were found in the substantia nigra of patients with Parkinson’s. At this level, iron works with neuromelanin inducing oxidative stress and death of the dopamine-making neurons. Liver is better than supplements if iron is deficient and low dose tincture of Rumex crispus (Yellow  dock) to gastric tolerance allows more efficient use of iron without increasing the mineral itself.  Start at 10 drops twice daily of a standard 1:5 tincture and work up gradually.
  • Silica, appears to have the effect, as silicic acid,of reducing the bio-availability of aluminum, avoiding its deposit in neurofibrillary tangles which is associated with dementia.  Horsetail weed supplements provide this in a bioavailable form.
  • Creatinine increases levels of phosphocreatine, an energy source in the muscle and brain, and in experimental studies it protects against nerve cell injury. The National Institute of Neurological Disorders and Stroke (NINDS) has now funded a multi-center pilot study of creatinine (along with another agent, minocycline) in people with Parkinson’s. For PD, doses of 5 to 10 grams daily are under study.  Creatinine should be used cautiously by persons with impaired kidney function.
  • Citicholine (CDP choline, cytidinediphosphocholine) CDP choline, also known as citicoline, is often used by victims of stroke or head trauma. It may also have benefit in memory loss and PD.  CDP choline may help repair damaged nerve cells in brains, including those that produce dopamine. CDP choline may also increase levels of glutathione, an antioxidant.  Initial studies of CDP choline in PD suggest it may be most beneficial for the symptoms of rigidity and bradykinesia. Doses of 500 mg to 2,000 mg daily, either taken orally or given as an injection, have been used. The most common side effect reported with CDP choline is slight stomach upset. Use as directed on the supplement bottle
  • Phosphatidylserine was found by Tel Aviv University’s Department of Human Molecular Genetics and Biochemistry to improve the function of rat genes involved in disorders such as familial dysautonomia and Parkinson’s disease. Phosphatidylserine has already been .. The substance contains a molecule known to be essential in transmitting signals between nerve cells in the brain, and mitochondria require a constant and well-regulated supply of phospholipids for membrane integrity.  200-300 mg daily.
  • L-Tyrosine may be useful depending on your medication.  L-tyrosine, which is the precursor to L-dopa should improve Parkinson’s disease symptoms, as L-dopa converts into dopamine. But L-tyrosine can interfere in levadopa’s transport, and the University of Michigan Health System recommends that you do not combine the supplement L-tyrosine with the medication levadopa or take L-tyrosine instead. It may be useful when combined with St. John’s wort but more research needs to be done.
  • Alpha-Lipoic Acid & Acetyl-L-Carnitine may lower oxidative stress and a slowing of potential PD.  ALA is believed neuroprotective by increasing acetylcholine and lowering the damage from damaging proteins especially in the substantia nigra.  ALA may lessen the depletion of glutathione, lowering free radical damage, mitochondrial dysfunction and the death of dopaminergic neurons. Together with Acetyl-L-Carnitine, ALA has been found to protect in vitro human cells against mitochondrial dysfunction, oxidative damage and accumulation of alpha-synuclein and ubiquitin. Most notably, when combined, ALA and ALC worked at 100-1000-fold lower concentrations than they did individually.
  • SAM-e There is evidence suggesting that levodopa medication can reduce brain levels of SAMe. This depletion may contribute to the side effects of levodopa treatment, as well as the depression sometimes seen with  Parkinson’s disease. One study found that SAMe taken orally improved depression without changing the effectiveness of levodopa.  However, it is also possible that taking extra SAMe might have a long term interference with levodopa’s effectiveness. Contraindicated for bipolar disease and can interact with other antidepressants.  Deficiencies in methionine , folate , or vitamin B 12 can reduce SAMe levels so those supplements may help prevent depression. DMT is another potential precursor.  SAM-e is not found in appreciable quantities in foods, so it must be taken as a supplement by itself.  200-400 mg taken 3 to 4 times per day.
  • 5-HTP may help with depressive symptoms in Parkinson’s disease when combined with Levadopa and Carbidopa but get appropriate pharmaceutical advice.  Less expensive than SAM-e.
  • Melatonin can be taken an hour before bedtime if you have trouble sleeping.  Try not to use melatonin frequently as it is a hormone your body should make.  Sleep hygiene (no late TV or computer, low light an hour before bed, a hot bath) and essential oil of lavender smelled in bed are better.
  • EDTA orally can help remove heavy metals gradually. While IV chelation has not been found (or disproven) to be useful for Parkinson’s due to heavy metal toxicity, oral EDTA chelation is inexpensive and unlikely to cause harm and usually benefits most people.  The idea of using a chelator for Parkinson’s disease is not unreasonable: we know iron accumulates in the Parkinsonian brain, and iron seems to accumulate in important brain areas known to be part of the neurodegenerative process – including the substantia nigra.  Additionally, there are a few animal experiments that have shown a protective effect of chelation against the development of Parkinson’s disease.  Take as directed on the bottle.  Suppository form show no additional benefits and are quite expensive. Read Dr. Gary Gordon for more.
  • Trace mineral concentrate, netttles or seaweed provide trace minerals no longer found in food. I squirt 10 drops of my trace mineral concentrate into my grapefruit juice or a day’s ration of coffee.  Eating nettles grown on good soil or clean seaweed also provides trace minerals.

Do not take all supplements.  Most people will benefit from magnesium, turmeric, fish oil, Vitamin D,  B vitamins and trace minerals.  Take melatonin only if you have sleep problems that do not respond to sleep hygiene suggestions and lack of sleep makes you dysfunctional.  Don’t take iron unless you test low and also have leg cramps that do not respond to magnesium, blood sugar control, massage and exercise.  Exercise for circulation before using supplements. Walk in sunlight out of doors and exercise for depression before using supplements. Use detoxification supplements for a course of treatment which could be three months:  take organic meals, seaweeds, milk thistle, turmeric and EDTA, while doing dry brush massage and infrared saunas.  Consult with your doctor, pharmacist, acupuncturist or naturopath to make sure you are not working at cross-purposes.

Herbs

Herbs are generally a safe way to strengthen and tone the body’s systems and as complex organic substances they tend to have cofactors and buffers. As with any therapy, you should coordinate treatment from a trained herbalist ( look for titles like RH (AHG), NCCAOM in Herbal or Oriental Medicine, an Oriental Medicine degree, MS degrees in Ayurveda, western herbs or equivalent study) with your MD and to diagnose the pattern of your problem before starting any treatment. You may use herbs as dried extracts (capsules, powders, teas), glycerites (glycerine extracts), or tinctures (alcohol extracts). It is generally best to take herbs in a form you can taste because the taste signals your body to use them. Unless otherwise indicated, you should make teas with 1 tsp. herb per cup of hot water. Steep covered 5 – 10 minutes for leaf or flowers, and 10 – 20 minutes for roots. Drink two to four cups per day. You may use tinctures alone or in combination as noted.

  • English: Turmeric root. Photo taken in Kent, O...
    English: Turmeric root. Photo taken in Kent, Ohio w  (Photo credit: Wikipedia)

    Ginkgo biloba 80 mg two times per day or 60 mils three times a day in tincture or liquid extract form.  Ginkgo leaf extract is an antioxidant that improves blood flow to the brain and may help with dopamine delivery.

  • Turmeric is an adaptogen which means it will balance your hormones and immune system and is nontoxic at  normal doses.  It helps with energy, liver detoxification, pain reduction and improved circulation.  In India it is considered a panacea herb.  I do not suggest taking it in curcumin capsules, even with bioperine from black pepper which enhances circulation.  Instead cook liberally with it (curries anyone?) or take turmeric honey on days when you don’t.
  • Mucuna pruriens contains levodopa. One small study showed that it had better results than the form of levodopa given as prescription medication. Doses ranged from 22.5 – 67.5 g per day divided in 2 – 5 doses. More studies are needed. Do not take cowhage without your doctor’ s supervision, especially if you already take levodopa. –
  • Brahmi (Bacopa monniera ) is an Ayurvedic herb that is often used to treat people with Parkinson’s. Studies suggest that it improves circulation to the brain, as well as improving mood, cognitive function, and general neurological function. Dosage guidelines vary, but some practitioners suggest 100 – 200 mg twice daily.
  • Milk thistle helps with liver detoxification and may be useful for dealing with high level toxins or side effects from medication. Milk thistle should be taken before meals with a tall glass of water. The usual dose is 70 mg to 140 mg three times daily.

Homeopathy

Homeopathy when it works, depends on resonance.  Unlike foods, meds and herbs which can allow significant improvement even when there is not perfect match with the patient, homeopathy appears to either work or it doesn’t at all.  Because of this you should consult a trained homeopath who can determine the right remedy for you and change it when your symptom picture (hence resonance) changes.

  • Argentum nitricum — for ataxia (loss of muscle coordination), trembling, awkwardness, painless paralysis
  • Causticum — for Parkinson’s with restless legs at night
  • Mercurius vivus — for Parkinson’s that is worse at night, especially with panic attacks
  • Plumbum metallicum — especially with arteriosclerosis
  • Zincum metallicum — for great restlessness, and depression
  • Mag-phos-for trembling; shaking of hands, cramps in calves, feet very tender. Twitching,worse on right side

Combined R-alpha lipoic acid and aetyl-L-carnitine exerts efficient preventative effects in a cellular model of Parkinson’s Disease  J Cell Mol Med. 2010 Jan;14(1-2):215-25. doi: 10.1111/j.1582-4934.2008.00390.x.

Nutritional Supplements and Vitamins: Alternatives to Help Parkinson’s Disease? Parkinson’s Disease Foundation

Low vitamin D concentration exacerbates adult brain dysfunction Am J Clin Nutr 2013 97: 5 907-908

EDTA and Chelation Therapy: History and Mechanisms of Action, an Update Garry F. Gordon, MD, DO, MD(H)

Calcium, copper, iron, magnesium, silicon and zinc content of hair in Parkinson’s disease  Journal of Trace Elements in Medicine and Biology 19 (2005) 195–201

Nutrition for Parkinson’s Disease acupuncturebrooklyn.com

How to Make Turmeric Honey for Inflammation acupuncturebrooklyn.com

 

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Nutrition for Parkinson’s Disease- Part 1

Nutrition for Parkinson’s Disease has four components: What to Eat, What Not to Eat, Useful supplements and How to Eat, given symptoms of the disease.  This will be a four piece series.  Some of it is basic: the foods and superfoods that enrich the diet.  Some is specific to the typical complaints from either the disease, the medications and the often restrictive lifestyles that PD patients often adopt.   And the how-to acknowledges that the disease creates some physical problems that adaptive devices might help.

Mucuna
Mucuna in flower, source of L.Dopa (Photo credit: Wikipedia)

Nutrition for Parkinson’s Disease Part 1:  What to Eat

People with Parkinson’s have some extra requirements in their diet.  Because shaking can burn calories, it is easy to become underweight, although that is not universal.  Yin deficiency, a kind of dehydration or wasting, is generally seen in symptoms like shaking, muscle spasms, constipation, poorly nourished muscles and skin, as well as dehydration.  Blood deficiency can be seen with pale skin, lips and tongue as well as with muscle wasting. While we have limited knowledge of what causes the substantia nigra to stop making dopamine, it is likely that missing nutrients will be implicated in both the production of dopamine and the preservation of brain cells. People with Parkinson’s often suffer from constipation and muscle  spasms. So what should you eat?

  • Berries and other fruits-  While people with Parkinson’s who are not overweight can eat fruit rather freely, it is best to deal with nutrient-dense berries.   Blueberries, huckleberries, goji berries, blackberries, raspberries, organic strawberries,  pomegranates, and cherries all pack a deeper nutritional punch than apples, pears and bananas.  All are useful, but especially the berries which are rich sources of flavonoids.  Blueberries and organic strawberries can reduce depression, improve memory and slow neuro-degeneration. Goji berries are especially high in antioxidants and can build blood.  Cranberries may protect the urinary tract. Tart cherries can help insomnia with their melatonin. Berries can pack in the nutrition especially as swallowing becomes more difficult.  Go for organic, especially with strawberries and other berries because chemicals in pesticides can be linked to Parkinson’s. All fruits provide fiber which can counteract constipation. 1/2-1 cup daily.
  • Purine-rich foods which break down too uric acid and then urates:  The chemical urate, a potent antioxidant which is known to cause gout in excess, appears to slow the progression of Parkinson’s disease.  Foods that make uric acid include:  fructose, asparagus, beer, heart, herring,mussels,yeast, smelt, sardines, and sweetbreads.  Just don’t overdo it, especially if you are prone to gout or insulin resistance.  A serving a day, but take it in the evening if you are on Levodopa or Carbodopa.
  • Fatty fish or fish oil including halibut, sardines, wild Alaskan salmon, anchovies and herring are rich in the DHA and EPA, Omega 3 fatty acids which go to the brain and help guard against dementia which affects some 40% of people with Parkinson’s.  Fish oil improves cognition, protects against depression, boosts the immune system,relieves arthritis and protects the heart.  I do not find flax oil as effective as fish or cod liver oil- it can require 30 times the dose, goes rancid very rapidly and some 30% of the population cannot convert it to DHA.  (DHA makes up 20% of grey matter in the brain.)  If you eat fish, eat the skin and check Seafood Watch to make sure that mercury levels are low. Beef that is 100% pasture-raised on grass has a fat profile similar to deep water fish but conventionally grain-raised CAFO beef does not.  Otherwise get cod liver or fish oil and take enough to get 1000 mg of DHA. Since that can be 5 capsules, I generally get Carlson’s lemon-flavored fish oil or Green Pasture’s cinnamon fermented cod liver oil and use it to wash down supplements.
  • Iron is linked to dopamine production.  Patients with Parkinson’s have lower levels of dopamine produced by the substantia nigra and may respond to iron administration. Iron, as a cofactor in dopamine production, plays a central role in the etiology of the disease. Low dopamine can cause other neurological problems such as restless leg syndrome and muscle spasms.  Judging from the Parkinson’s people I see, Blood Deficiency is pretty  widespread. I recommend pasture-raised organic red meat, liver once a week,and dark green and dark red vegetables. (Chlorophyll is hemoglobin with magnesium at the center instead of iron, but usually has non-heme iron as well.)  To increase iron absorption, tincture of Yellow dock (Rumex crispus) given in drop doses to stomach tolerance, can be helpful. However taking iron as a supplement can be ineffective (hard to absorb), hard on your heart or absorbed by bad gut flora.  Dr.Campbell-McBride advises against it :

 Most people with abnormal gut flora have various stages of anemia. It is not surprising. They not  only can’t absorb essential for blood vitamins and minerals from food, but their own production of these vitamins is damaged. On top of that people with damaged gut flora often have a particular group of pathogenic bacteria growing in their gut, which are iron-loving bacteria (Actinomyces spp., Mycobacterium spp., pathogenic strains of E. coli, Corynebacterium spp., and many others). They consume whatever iron the person gets from the diet, leaving that person deficient in iron. Unfortunately, supplementing iron makes these bacteria grow stronger and does not remedy anemia.” (Gut & Psychology Syndrome)

Vinegars made with live mothers are probiotic
  • Probiotic Foods help you develop good gut flora that can out-compete undesirable bacteria and to increase digestion.  Live blue cheese, yogurt, kefir, sauerkraut, kimchee, vinegar with a mother like Braggs, kombucha, unpasturized  pickles and olives, miso, fermented fish sauces and pickled vegetables should be taken at each major meal.  Pickles and pickle juice helps the body free up magnesium which can reduce cramps.  Other bacteria help absorb minerals.  I prefer food-based sources of probiotics because you eat them fresh, they come with their own prebiotics which feed them and tend to have a variety of organisms that may not be in pill form.  For instance, most probiotic pills only have lactobacillus or bifidobacteria but there may be another 500 species that are present in a healthy gut. If you do use probiotic supplements, look for them in a refrigerated case rather than a shelf.
  • Prebiotic foods feed the gut flora and can protect against iron depleting strains of bacteria.  Prebiotics like  fructooligosaccharide (FOS) and inulin feed the probiotic organisms and allow them to proliferate in the gut.  They ought to be in probiotic supplements to help keep them alive.  However your gut also needs to be receptive to them.  Rather than purchasing a prebiotic supplement, eat a serving of Jerusalem artichokes, asparagus, onions, leeks, burdock root, garlic (in quantity), shallots, jicama root, chicory or dandelion root, barley or yacón each day.
  • Nuts from trees are great sources of Vitamin E in its various forms and trace minerals, as well as good fats provided you eat them raw.  Roasting can easily change the fat profile and excessive conventional salt triggers indiscriminate consumption.  You will absorb nut nutrients better if you soak them overnight- you can puree them into nut butter with a little sea salt, toss them into salad or a stir fry or make your own nut milks. They are storehouses of important trace minerals:  Brazil nuts are high in selenium which can help the heart.  Peanuts which are ground nuts are significantly contaminated with aflatoxin, a known carcinogen that is twenty times more toxic than DDT. Since toxins can cause some Parkinson’s, avoid peanuts. 1 oz . per day of tree nuts.
  • Beans in general are good for Parkinson’s because the fiber levels are high enough to prevent constipation while providing protein, reducing blood sugar spikes and providing  protection from cancer. They can be consumed daily with herbs like rosemary or bay leaf to reduce flatulence and making them yourself will allow you to change the water enough to reduce that problem.  But there are two beans in particular which provide special protection against Parkinson’s:  fava beans and mucuna beans.   These beans contain levodopa, the same chemical in Sinemet, Madopar, Dopar, Larodopa, and other levodopa-containing medicines used to treat PD which means that adding them to a well-balanced prescription can be problematic, although they can sometimes substitute for all or part of a prescription. According to Dr. Jame’s Duke’s database the entire fava plant, including leaves, stems, pods, and immature beans, contains levodopa, with the highest concentrations in the flowers and sprouting bean. The amount of levodopa can vary greatly, depending on the species of fava and where it’s grown especially since it has been cultivated as a food rather than a medicine for most of its history.  Three ounces (about 84 grams or ½ cup every day) of fresh green fava beans, or three ounces of canned green fava beans, drained, may contain about 50-100 mg of levodopa. One small study showed that mucuna had better results than the form of levodopa given as prescription medication and anecdotal evidence shows it tends to work better than fava beans. Doses range from 22.5 – 67.5 g per day divided in 2 – 5 doses.  Neither bean should be taken by persons with Monoamine oxidase inhibitors (MAOI) or elevations in blood pressure may result.  If you have favism, a genetic susceptibility where you lack an enzyme called glucose-6-phosphate, eating fava beans could cause a condition called hemolytic anemia.  This is ruled out by a test but it is unknown if mucuna also causes this reaction.  Lacking either MAOIs or Favism, both beans are potentially good for people with  Parkinson’s who work with an herbalist and medical doctor.
  • Cruciferous Vegetables like broccoli, cauliflower, cabbage, kale, bok choi, kohlrabi, brussels sprouts and mustard, rutabaga and turnip greens help reduce estrogen dominance which reduces magnesium and vitamin B. A deficiency in magnesium causes muscle tightening and that causes people to experience  muscle spasms while deficiency in vitamin B can cause neurological problems like neuropathy.  Cruciferous vegetables are rich in zinc, vitamins A, B, C, D and E and  Indole-3-Carbinol (I3C) which is especially beneficial to estrogen metabolism. When I3C combines with stomach acid it creates 3,3-Diindolylmethane, or DIM. The metabolism of DIM overlaps with estrogen metabolism so that it promotes healthy estrogen metabolism.  Eat 2-4 servings daily within your 9 servings of veggies and berries.  They should be steamed or in the case of kale chips, dried with heat to protect the thyroid.

  • Coffee and Tea. Coffee has shown to be helpful at both preventing and slowing the progression of Parkinson’s disease in a dose-dependent way.   Coffee consumption is associated with 60% fewer cases of Parkinson’s Disease in one study. Caffeinated coffee is better than decaf and coffee reduces symptoms better than other sources of caffeine, indicating that caffeine alone may not be the protective mechanism. (Coffee is much more than caffeine, with magnesium and potent antioxidants like the chlorogenic acids.) Caffeine as an isolate incidentally was associated with better motor control but had very little effect on daytime sleepiness.  One caveat:  some people don’t do well on coffee and tend to self-select out of  the positive scientific studies (try making a coffee placebo!) Follow your own body.  Tea has general health benefits from catechins which are powerful antioxidants and at least one study showed a reduced risk of Parkinson’s disease.  There is some evidence that symptoms may be reduced with tea drinking, especially in studies of Asian populations.
  • Other Fluids:  Since dehydration is a problem, you need to drink.  Drinking more than a half cup at a time triggers the urinary reflex so does not hydrate your tissues.  So put your water in a bottle with a drink-through cap and sip it  through the day.  If you drink coffee or soda, assume that the caffeine will reduce hydration by 25% and tea or iced tea by 10%.  Don’t drink soda though, especially cola or artificially sweetened soda which contains potential toxins not known to be safe for Parkinson’s.  If water seems too plain, add a spear of melon and a sprig of mint, or sliced lemons or fresh rosemary and orange slices. Coconut water has a good balance of electrolytes and isn’t too sweet. You can also get fluids from fruits like watermelon or citrus.  But if you can get fresh vegetable juice with lots of greens, it would be better from a nutritional standpoint. Don’t forget good fats- think of oil floating on water to prevent evaporation.
Mai men dong (ophiopogon tubers) make a mild soup ingredient that strongly tonifies yin. Available at Chinese grocery stores.
  • Yin building herbs and foods:  Parkinson’s disease can be dehydrating, drying out skin, muscles, the colon and joints. This is referred to as yin deficiency and can develop into deficient (friction) heat as it progresses. You need to nourish your fluids and tissues and there are a number of “Chinese grocery store”  or food grade herbs and foods that can help.  Seaweeds should be included in the diet at least twice a week, but dulse, nori and kelp are also available as sprinkles that can be used like a flavored salt inbetween.  Seaweeds are good sources of trace minerals and iodine, since much of our healthy topsoil has blown out to sea.  A table spoon or two of slippery elm or marshmallow powder can be stirred into applesauce or oatmeal.  Mai men dong bulbs (opiophogon, liorope) are small, bland Chinese vegetables that nourish yin, go well in even western soup and can be found at Chinese grocery stores.  So can white lily bulb (bai wei), broken into small bulblettes.  Shatavari (asparagus tuber, tian men dong), the yin adaptogen food can be found online powdered, and can be used to thicken soups while nourishing fluids, hormones and tissues.  Oatmeal, millet, alfalfa sprouts, artichoke, asparagus, kelp, mung bean sprouts, okra; peas, potatoes, black beans, avocado, aduki beans, seaweed, string beans, sweet potatoes, tomatoes (especially tomato paste), water chestnuts, yam, zucchini, berries, apricots, pears, watermelon, fish and shellfish, pork (especially liver and kidneys), beef, goose and duck, coconut milk and nuts all will help keep you supple.  9 servings of  yin-tonifying fruits and vegetables a day.
  • Foods with B vitamins, especially B1 thiamine, B5 pantothenic acid, B9 folate, B12 cobalamin, B6 pyrodoxine help the mitochondria which power our cells . Foods high in B vitamins include purple and green kale, mushrooms, bok choy, collards, rare organ meats like liver, heart and tongue,  and very rare muscle meat.  Meats are better sources when organic and grass fed. However if you can’t find grass fed liver, the organ has numerous detoxification pathways so you are safe with conventional liver- akin to an apartment building with a full janitorial staff.  This is not true of other organs.
  •  Iodine is important for Parkinson’s.  It not only necessary for the production of thyroid hormone, it is also responsible for the production of all of the other hormones of the body. Adequate iodine levels are necessary for proper immune system function. Iodine contains potent antibacterial, antiparasitic, antiviral, and anticancer properties. Iodine deficiency disorder can result in mental retardation, goiter, increased child and infant mortality, infertility, and socioeconomic decline. There is evidence that Parkinson’s is more prevalent where iodine is missing in the soil and  in areas where goiters are frequent. Long-term iodine deficiency appears linked to abnormalities in the dopaminergic system that include an increased number of dopamine receptors. This raises susceptibility to dopamine oxidation which, in turn, causes deficiencies of the antioxidant enzymes Copper or Zink superoxide dismutase, glutathione peroxidase and catalase. Dopamine deficiency also leads to elevated cytotoxic glutamate levels. Iodine is primarily found in seawater in very small quantities and solid rocks (usually near the ocean) that form when seawater evaporates. Iodine can also be found in seafood like halibut, salmon and shellfish and seaweeds like kelp, dulse, nori and hijiki. In fact, seaweed is one of the most abundant sources of iodine because seaweed has the ability to concentrate a large amount of iodine from the ocean water.  Seaweeds and seafood should be taken twice a week from low mercury sources.
  • Kitchen Spices:  There is often a loss of taste or smell with PD, and the use of strong spices like thyme, oregano, rosemary, ginger, tulsi (holy basil which is sharper than regular basil), cardamon and star anise are not only strong antioxidants but have penetrating flavor and can enhance cerebral circulation.  Do not forget that people with impaired taste can often perceive sour flavors like lemon juice, and vinegar or salty tastes (use seaweed granules, Celtic sea salt, Himalayan salt, iodized sea salt but no MSG.)  But turmeric is the king of anti-inflammatory spices.  Turmeric is an adaptogen that is strongly antioxidant and anti-inflammatory, which crosses the blood brain barrier and is neuroprotective. It is considered a panacea herb in Ayurvedic medicine. It is used in curries, soups, smoothies and in milk.  My favorite way to take medicinal doses is to take 10 oz. dried turmeric, 1/2 ounce freshly ground black pepper and 1/2 oz. ground ginger and mix well.  Then stir in a local honey until it has the texture of cookie dough.  Take a heaping teaspoon once or twice a day.
  • Good fats and oils:  Most seed oils or conventional cooking oils are too high in Omega 6 fatty acids at a time when the Omega 6/Omega 3 fatty acid ratio (PUFA) has gone from 2/1 to 30/1 today.  I recommend avoiding seed oils in favor of fruit oils like coconut oil and olive oil.  For cooking you need a more saturated oil like coconut oil that will not peroxidize (go rancid).  Ghee or animal drippings from grass-fed organic animals won’t distort under heat either compared to other oils.  For raw consumption, avocado, olive oil, black seed oil (see below) and lemon flavored fish oil are useful.  Coconut oil with its ketones has, according to case histories, caused a reversal of Alzheimer’s dementia so is worth considering for the cognitive decline of Parkinson’s or Lewy’s dementia.  It also offers protection from viral diseases.  1-3 tablespoons in oatmeal or other food.  It is being sold as an expensive functional food for Alzheimer’s.
Fresh Turmeric Root
  • Seeds are something I tend to avoid because we get too many Omega 6 oils in our diet, but a few are outstanding exceptions.  Flax seed, hemp seed, black seed and black sesame seeds all help nourish the bowel and help stop constipation, but each has specific virtues.  Flax seed has Omega 3 fats that some people can, through genetics and good lifestyle, convert to DHA and EPA.  You need to grind it to get the Omega 3s but the lignins in the skin do have some laxative benefit if you don’t. It goes rancid very fast and I recommend getting a coffee grinder and grinding immediately before eating.  It is good in oatmeal, over salads, in yogurt and preground in smoothies.  Hemp seed is currently either steamed or shelled  in the US so that it cannot grow.  It is a good source of Omega 3s but can also go rancid easily.  I prefer to make hemp milk or to use it in smoothies.  Black sesame seed (He zhi ma) tonifies both Liver and Kidney yin, nourishes blood and secures Essence. Black sesame seeds are very rich in iron, magnesium, manganese and copper. There are about 90 mg of calcium in one tablespoon of unhulled (black) seeds It is used in both food and medicine, especially for women and the elderly but since Parkinson’s patients of both sexes are often Blood deficient, don’t let tradition stop you.  Black seed (Nigella, black cumin) is used widely in the Middle East, as seed or oil.  It smells something like thyme and facilitates a healthy inflammatory response including cell signaling chemicals and hormone-like messengers.  Small amounts are put in string cheese and pickled Moroccan lemons, over salads, in pilaf or it is used medicinally.  According to Mahfouz and El-Dakhakhny:

Ladybug on Fava bean flower

“Two of the most volatile oils found in Black seed are nigellone and thymoquinone which were fist discovered in the herb in 1985. Nigellone offers both anti-spasmodic and bronchodilating properties which contribute to Black Seed’s potency against respiratory ailments. It also acts as an antihistamine which helps to reduce the negative symptoms of allergy sufferers. Thymoquinone contains excellent anti-inflammatory and analgesic properties. It is also a strong anti-oxidant and helps cleanse the body of toxins. Both nigellone and thymoquinone work in conjunction with one another to enhance Black Seed’s action against respiratory ailments. It also provides a healthy alternative to the more commonly prescribed cortisone based therapies used by allergy sufferers. Black seed provides a rich supply of polyunsaturated fatty acids. These ingredients play a key role in daily health and wellness. They help to regulate the metabolism, carry toxins to the skin’s surface for elimination, balance insulin levels, regulate cholesterol, improve body circulation, and promote healthy liver function. A deficiency in polyunsaturated fatty acids can lead to a wide number of health problems including nervous system disorders, uninhibited growths, and skin diseases. Black seed contains over 100 valuable nutrients. It is comprised of approximately 21% protein, 38% carbohydrates, and 35% plant fats and oils. The active ingredients of black seed are nigellone, thymoquinone, and fixed oils. Black seed also contains significant proportions of protein, carbohydrates and essential fatty acids. Other ingredients include linoleic acid, oleic acid, calcium, potassium, iron, zinc, magnesium, selenium, vitamin A, vitamin B, vitamin B2, niacin, and vitamin C.”

To summarize, you should get 7.5-8 servings of vegetables per day including at least 2 cooked cruciferous vegetables and the majority from the yin-tonifying list. Choose colored vegetables like butternut squash or cooked carrots for at least one serving.  At least one serving should be fermented to provide probiotic organisms (sauerkraut, kimchee) and twice a week sea vegetables (seaweeds). One serving of berries or tart cherries a day and one-half to one serving of other fruit.  Wild salmon or other fatty fish twice a week. Liver once a week. Organic pasture-raised meat, preferably organ meat on other days.  Beans especially black beans several times a week.  One ounce of tree nuts or nut butter daily. Organic eggs, preferably with a raw yolk daily. Spice your food with strong herbs, turmeric and ginger.  Sprinkle in flax seed, black seed, black sesame or hemp seed daily.  Two to four cups of coffee, two liters of water and two cups of other beverages.

Also see Kathrynne Holden‘s book on nutrition for people with Parkinson’s, Eat Well, Stay Well with Parkinson’s Disease which is available through Amazon or for download here.  While  she has somewhat more conventional food choices than make it through my Chinese medicine/herbalist lens, she has worked with PD for many years, has special expertise about food/medicine interactions and has dealt with malnourished people with Parkinson’s in both hospital and clinical settings.

I would be remiss if I did not mention Dr. Terry Wahls who suffers from MS but found a way of eating that took her from a tilt-recline wheelchair to riding horses and freely biking today.  She eats a variation on a paleo diet that is primarily vegetable based, specifically designed to support the brain and mitochondria. This is especially important for people with Parkinson’s, ALS, Huntington’s, PTSD, migraines, dementia and MS.  The vast majority of people do not eat to support life and need some significant changes. I urge you to take the time to watch her TED Talk.  If you want more, she has a video class on nutrition and the brain :

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Two Year Low Cal/Low Carb Diet Study Misleading

A two year, $4 million  studyof 307 people, purporting to compare low carb to low fat diets has been completed, apparently showing similar weight loss after two years, but improved blood lipids for people who followed the low carbohydrate diet. They tell us study results show it doesn’t matter which way we diet.   But the study has several problems:

  • The low carb diet went for 12 weeks, after which people were encouraged to add 5 grams of carbohydrates daily for a week, increasing carbohydrates until their weight stabilized.
  • The low calorie diet went on for 2 years.  So a short term diet was compared to a long term diet.
  • No one looked at actual food intake.  Yep, a diet study with no data on what people actually ate eventhough they kept food diaries.
  • And data from dropouts was extrapolated and included, or as the rest of us call it, the data was made up.

Why Would You Include Data from Dropouts?

The last point may need some explanation.  Usually one would compare only people who followed the protocol, but in recent years people wondered what happened to the dropouts.  Why would you ever look at data from people who didn’t follow the diet?  It seems counterintuitive, but there are legitimate questions here, if  too many people drop out of a study it may be because the protocol causes real life problems.  If you are looking at what is called “Intent to Treat” then you might well look at the end result to see if prescribing a certain course of action is likely to help in the real world where people don’t always follow directions. It tells you what people might do in an experimental context, not which course of action is better.   But you want to use real end data on the dropouts, and to segregate it from the compliers.  If you mix the data together, then it is impossible to tell whether Protocol A (say a low carbohydrate diet) is better than Protocol B (say,  a low calorie diet) when people follow directions.  In other words, you would never use Intent to Treat (ITT) in a comparison of which diet is actually better.  An ITT analysis can draw the exact opposite conclusion to a traditional analysis.  But the researchers did just that in this study.

“To assess departures from the missing-at random assumption under informative withdrawal-that is, the missing weights are informative for which patients chose to withdraw or continue to participate in the study-we present sensitivity analyses. As such, we assume that all participants who withdraw would follow first the maximum and then minimum patient trajectory of weight under the random intercept model.” (italics mine)

So they did not use real outcomes for the noncompliers or even assume that the real outcomes on the others would apply.  They extrapolated them based upon a model that significantly understates the difference between the two groups. (They spent more time and charts on the model than on the real data, not all of which is reported in the full text study.)  That means the data were made up based on the group that continued, not at the average rate, but at the “minimum trajectory”.   In other words they extrapolated at the low end of the data, which minimizes the effectiveness of the diet.  Consider that adding in the dropouts alone can make significant differences.  Richard Feinman who has looked at Intent To Treatment gives the following table showing how ITT masks the true response of those that follow a low carb diet in two prior studies:

Weight Loss in Diet Comparisons and the Effect of Analysis.
    Data for 12 months Weight Loss (kg)
 


 

    With Drop-outs SD Only Study Subjects SD
 


 

Foster, et al. low carb 4.4 6.7 7.3 7.3
  low fat 2.5 6.3 4.5 7.9
  difference 1.9   2.8  
 


 

Stern, et al. low carb 5.1 8.7 7.3 8.3
  low fat 3.1 8.4 3.7 7.7
  difference 2   3.6  
 


 

Feinman Nutrition & Metabolism 2009 6:1   doi:10.1186/1743-7075-6-1

Frank Hagensays “if you use the numbers that include the people who dropped out of the diet, in the “With Drop Outs” column, where the low carb group in the “Foster, et. al.” study only lost 1.9 kg more than the low fat group. But look at the column titled “Only Study Subjects”, comparing those that actually followed the low carb or low fat diet, and you find that the low carb dieters actually lost 2.8 kg [6 pounds] more than the low fat dieters (47% more weight). For the “Stern, et. al.” study, we find even greater numbers: a difference of 2 kg between the diets using ITT and 3.6 kg [8 pounds] when counting those that actually followed the diet plans. That’s 80% more weight loss.”  As you can see, the difference in outcomes is quite a bit more distinct when dropouts are not included.

In this study,  the authors did not segregate the data  for only people who followed the diet.  So we do not know what percentage of the low carbohydrate dieters were still on a low carbohydrate diet at the end nor what percentage were on a low calorie diet.  Judging from the triglyceride rates which drop when carbohydrates are low, few of the final group of dieters were still on a low carbohydrate diet. This is confirmed by the higher level of urinary keytones at 3 and 6 but not 12 or 24 months.  But that would happen anyway because of the design of the study.

Triglyceride Effects:

Diet Group 3 Mos. 6 Mos. 12 Mos. 24 Mos.
Low Fat -17.99 -24.3 -17.92 -14.58
Low Carb -40.08 -40.06 -31.52 -12.19

What Is A Low Carbohydrate Diet?

Common sense would say that to compare two diets, one low carbohydrate and one low calorie, you need to have some sort of set criteria for what is eaten and to run both diets similarly.  In the study, the low carb group had a very low carbohydrate induction phase followed by gradual increases of 5 grams daily each week, increasing indefinitely.  The low fat group did not increase calories during this time.  As the abstract says:

A low-carbohydrate diet, which consisted of limited carbohydrate intake (20 g/d for 3 months) in the form of low–glycemic index vegetables with unrestricted consumption of fat and protein. After 3 months, participants in the low-carbohydrate diet group increased their carbohydrate intake (5 g/d per wk) until a stable and desired weight was achieved. A low-fat diet consisted of limited energy intake (1200 to 1800 kcal/d; ≤30% calories from fat). Both diets were combined with comprehensive behavioral treatment.

Low Carb Diet Pyramid (not based on Atkins), if you must have a pyramid

Now if you are on a low carbohydrate diet for 12 weeks months, and then transition to a higher carbohydrate diet, with no outer level specified, then you are off of the low carbohydrate diet  at 100 g daily  by week 28 (or 6 months )and on a high carbohydrate diet of over 150 grams ten weeks after that. At 12 months, you’d be up to 210 grams per day which probably causes weight gain.  So even those who followed the protocol were not on a low carbohydrate diet for most of the two years. We are comparing a low-calorie weight-loss diet that lasted for two years with a low-carb diet that reached maintenance level within 6 months.

The study suggested only continuing the additional carbohydrates “until desired weight was achieved”  but since the average starting weight was 226 pounds, and average weight loss was 27 pounds at maximum, then “desired weight” was never achieved.

A better design would probably had the induction diet for two weeks, followed by a 60-80gram low carbohydrate diet for the entire period.  This is the methodology used in the Atkins diet books which the researchers claim they were using.

And What Were The Results?

According to the study, “During the first 6 months, the low-carbohydrate diet group had greater reductions in diastolic blood pressure, triglyceride levels, and very-low-density lipoprotein cholesterol levels, lesser reductions in low-density lipoprotein cholesterol levels, … had greater increases in high-density lipoprotein [good] cholesterol levels.”  The low carb group also had more adverse effects, primarily bad breath, constipation, and dry mouth during the first six months of the study which all could have been avoided with some simple counselling on which foods to eat.
Let us look at the results while participants were still on the low carb diet at 6 months:

Indicator          Low Fat          Low Carb

Weight loss          25                          27     pounds

Triglycerides     -24.3                  -40.6

HDL                          +0.9                  +6.2

TGL/HDL                 2.15                   1.39     (under 2 preferred)

As we can see, all parameters were better with a low carbohydrate diet at the 6 month period when carbohydrates had just reached maintenance levels.  Curiously blood sugar was not tested although most participants are likely to suffer from Metabolic Syndrome (diabetics were excluded.) The advantage continued at 12 months although by that time carbohydrate levels were approaching the weight gain level and some of the weight gain was noted.  By 2 years, only the gain in good cholesterol persisted, although in fact there was a “strong trend” to lower blood pressure in the formerly low carbohydrate group.

At the end of two years, while the low fat group was still dieting and the low carb group had been off their diet for a year, weight loss was the same (well there was slightly more weight loss in the low carb group but  it wasn’t considered significant.)  This should be news, although I admit the story is still muddled.  It certainly doesn’t lead to the conclusion that the type of diet doesn’t matter though, as the researchers have been saying.

Ketones and Low Carbohydrate Diets

Ketone Production

Why would they design a weight loss study this way?   Tom Naughton looked up the papers the researchers had previously done, and found a bias for low fat diets in their previous research.  I don’t necessarily suspect that they deliberately were seeking to waste $4 million or to mislead the  public about diets.  I think that the bias about a ketogenic diet’s safety and an imcomplete knowledge about how it works probably biased the study design.  First off, the Atkins diet, upon which the low carb diet was ostensibly based, starts with an induction period (usually 2 weeks of an extremely low carb ketogenic diet) and then adds carbs gradually until just before the body stops producing ketones, somewhere between 60-80 grams for most people.  It doesn’t add carbs forever.

Ketones are normal byproducts of burning fat which are water (blood) soluble.  These blood-soluble  fats are a source of energy for tissues including the muscles, brain and heart. Ketones can significantly substitute for sugar in the brain.  But both ketosis, a normal way of extracting energy from fat, and ketoacidosis, a dangerous  condition where the body is breaking down its own tissues from starvation or Type 1 Diabetes, produce ketones.  Ketones are easily measured  but distinguishing the cause is not.  So the presence of keytones seems to send off alarms even when the cause is benign.  I have heard many doctors and nurses caution against ketosis in a low carb diet “just to be sure” when what was really dangerous would be ketoacidosis- ketosis is the point of most low carb diets because it indicates burning fat.  This study did measure ketones, but didn’t distinguish between the causes, so treats the presence of ketones in the urine as potentially dangerous.  This causes me to believe that the researchers wanted to limit the time spent in ketosis, and sloppily did not put an upper limit on carbohydrates.  Unfortunately there is no discussion of the carbohydrate increase design in the study.

Low carbohydrate diets have been shown to increase weight loss in a number of studies including the current diet, the last Foster study and the Stern study discussed above,  but their reporting has been often distorted because of the low fat bias in nutrition which has been in effect since Ancel Keys promulgated the lipid hypothesis  based upon highly selected country data in 1963.  For instance in the Farmington study, high fat diets were associated with lower rates of most cancers but the headlines and research summaries focused on the few, less common cancers that were associated with high fat diets.  The researchers indicated that they wouldn’t have gotten funding for further analysis afterwards.  (Atkins archives).  A meta study (now withdrawn) by the Cochrane Group showed a weighted average of 5.1 vs 7.5 lbs at 12  months, but was reported as “no significant difference”.   A 2006 study by vegan-proponent Neil Barnard showed that a low glycemic index, flourless, vegan diet, that had fewer carbs than the American Dietetic Diet, was healthier, but it was not described as lower carbohydrate or even low grain diet.  The ADA diet has 6-11 servings of grains or starches a day plus fruits and vegetable sources of carbohydrates, giving approximately 220 g per day and allows unhealthy refined starches and vegetable oils (also avoided by the vegan group).   Only now, since Gary Taube’s New York Times article What If It’s All Been a Big Fat Lie? blasted through the establishment anti-fat bias, have low carbohydrate diets been considered potentially allowable.

Blood lipids and blood pressure were better for those who followed the diet

If you only look at weight loss, the differences between a low carbohydrate and low calorie diet are minimal unless the low carb diet is ketogenic, but the low carb diet has a slight advantage.  If you look at overall health parameters including blood sugar, HDL, TGL and blood pressure, a low carb diet has distinct advantages.  Based upon this study at every point there was no difference in bone loss.  During an induction period there are significant side effects to a low carbohydrate diet for 7-16 days, including a dry mouth, bad breath, headache and constipation but these will pass after the sugar withdrawal symptoms pass- essentially you are coming off of a drug.  Mineralization, lots of green vegetables and adequate hydration will help prevent this.

If you wish to learn more, including ways of transitioning with fewer side effects,  I cannot suggest anything better than  Paul Bergner’s course “Insulin Resistance: Pathophpysiology and Natural Therapeutics” which puts everything together with CDs and over a hundred pages of resource materials.  (I have no financial interest in promoting this, but it is the best I have found.”)

Sources:

Eades, Michael.  Metabolism and Ketosis

Foster, et. al. Weight and Metabolic Outcomes After 2 Years on a Low-Carbohydrate Versus Low-Fat Diet A Randomized Trial

Feinmann, Richard.  Intent to Treat:  What is the Question?

Hagen, Frank.  Lies, Damn Lies and Statistics.

Howard BVet al.: Low-fat dietary pattern and weight change over 7 years: the Women’s Health Initiative Dietary Modification Trial.

Howard BV, et al.: Low-fat dietary pattern and risk of cardiovascular disease: the Women’s Health Initiative Randomized Controlled Dietary Modification Trial.

Naughton, Tom.  Another Biased Study? Maybe…

Naughton, Tom.  Inside Information from “Fat Throat”

Barnard, N. Diabetes Care, August 2006; vol 29: pp 1777-1783. News release, Physicians Committee for Responsible Medicine.

Cochrane Database.  Advice on Low Fat Diets for Obesity.

Taube, Gary.  What If It’s All Been A Big Fat Lie?

See Also:

What Does Research Say About Eating Meat?

Fructose, Sugar, Poison and Obesity

The China Study Misrepresents Data: Does Not Support a Vegan Diet.

Strategies for Insulin Resistance

Simple Ways to Support Brain Function

 

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Staging Herbal Formulas to Enhance Fertility

Red Clover (Trifolium pratense)
Red Clover  Image via Wikipedia

Many women respond to single herbs or single formulas in their quest to get pregnant.  A strong overnight infusion of red clover, or red clover mixed with nettles and oatstraw has pushed many women over the brink from infertility to fertility.  This seems to work best when a little extra nourishment is needed in an otherwise healthy woman.   But hormones are complex, and the reasons why they may be out of balance are varied.

But before giving targeted formulas , the first thing I suggest to women is that they check their nutrition.  While I believe that women with a variety of fruits, vegetables and meat in their diets probably do not need to supplement most vitamins, minerals are another thing entirely.  Between the mid 1970s and mid 1990’s the USDA tested the nutritional content of food and found most minerals declined by a third due to soil depletion.  Magnesium is one of the most important, but zinc, boron and a number of trace minerals are also significant.  I suggest at least 500mg of magnesium plus a multi-mineral or trace concentrate supplement.   Fish oil sufficient to provide 1000mg of DHA (several capsules) will help keep the cell membranes of your egg responsive to the sperm.   Vitamin D is not really a vitamin, but a pro-hormone and  you probably need 5000-10,000 iu (a quarter to half of a physiological sun dose.)  If you live north of Atlanta, are fat, have diabetes or have dark skin, you probably need more.  Folic acid is very important to prevent birth defects and is found in a good quality prenatal formula which you should take in anticipation of getting pregnant.

It is important to know how to use herbs for fertility since there are so many causes.  Missing minerals, insulin resistance, lack of essential fats, lack of protein, strong fears of motherhood or pregnancy, low quality menstrual cycles, silent infections like chlamydia or gonorrhea, blocked fallopian tubes, PCOS, aging eggs and sperm, and many other factors affect fertility and the remedies are all different.

The menstrual cycle has clearly defined parts as you can see on the bottom of this article (click to enlarge).  The first part of the cycle, from bleeding to ovulation is ruled by Yin and is characterized by climbing estradiol (one of the estrogens) which rises to spike just before ovulation.  That is followed by short spikes in FSH and LH during ovulation, which trigger progesterone for the Yang luteal phase.  The pattern must be balanced to have enough Yin for a high estrogen spike, to have a good temperature differentiation between the Yin and Yang phases of the cycle and to have a high enough transition to allow the egg to be released.

Basal Body Thermometer and Chart

How would you tell if your menstrual cycle is not well balanced?  In Chinese medicine we always normalize the menstrual cycle of the woman to get her pregnant. I find that it is easier to get pregnant if you actually follow your cycle by charting your basal body temperature and check your cervical mucous.  To do this you keep a basal body thermometer (a digital thermometer that has an extra decimal place) by your bed and take your temperature before you start moving around.  You plot the temperature on some graph paper or a chart You can find instructions for taking your temperature and making a chart here.  Typically you see a low fairly steady temperature until about 12 days after you start menstruating.  The temperature dips slightly, spikes high at ovulation and finishes higher.  You can see an example on the chart at the bottom of the page, in the second band.

The chart is often used by women to decide when to have intercourse (just before and after ovulation) but a skilled practitioner can use it to choose herbs and to rebalance the cycle.  For instance if the temperature is sawtooothed there may be Liver Qi Stagnation and herbs to move the liver and release emotions may stabilize it.  The follicular (Yin, estrogen) phase may be too short or the luteal (Yang, progesterone) phase too long, so you may tonify Yin with herbs like rhemannia.  The ovulation spike may occur but not be high enough to actually release the egg and vitex may be helpful.  The progesterone phase may not produce a high enough temperature to prevent miscarriage so Yang tonics like walnuts and red meat are needed.  The entire cycle may be too short or too long.   Different herbs would be selected for different conditions and for different constitutional types.

Shatavari tonifies Yin

There are many reasons to consider giving different formulas during different phases of the menstrual cycle in order to enhance fertility.   A simple way is to give Yin-tonifying herbs (with a touch of Yang) from menstruation to ovulation (the follicular phase) and Yang tonifying herbs during the luteal phase.  Typically  the Yin tonifying formula Rhemannia 6 (Liu wei di huang wan) is given up until ovulation and a pregnancy-safe version of the Yang tonifying formula Rhemannia 8 (Jin gui shen qi wan) post ovulation.  The formulas are identical except that the yang tonifying formula has two extra warming herbs and they can be mixed and matched for partial conditions.   Sometimes a third formula will be given during the few days of ovulation, especially if there is a FSH or LH defect in the cycle.

However a woman goes through more than two different hormonal processes during her menstrual cycle. In the first phase she ripens the egg and builds the endometrium in her womb, which depends upon  Kidney Yin and Blood.  In the second , Liver Q and Blood movement govern ovulation.  In the third phase  Kidney Yang and Spleen Qi regulate the luteal stage or hold the pregnancy if it occurs.  In Phase 4, when PMS is most prevalent, Liver Qi helps the premenstrual transformation.  And Phase 5 is menstruation, covered by Blood and a little Qi to keep it moving.

It is not necessary to come up with five formulas unless the cycle is seriously disturbed.   If only one part of the cycle is not functioning well, you can target it.  This is not only done by, say giving vitex which increases progesterone during the luteal phase.  Instead I might use magnesium and zinc throughout the cycle as these help the body form progesterone itself.  Or I might add a little warming cinnamon and maca to the Yin phase of the formula in order to give the yin enough oomph to transform to yang at ovulation.

Menstrual Phases and Herbs

Phase

Ruled By

Supportive Herbs

Lifestyle

Follicular

Kidney Yin Rhemannia Sleep
Blood Goji berries Nourishing conditions
Slippery elm Water
Peony root Walks by Streams
Black sesame seeds Dark red and green foods
Seaweeds Black and Blue Foods
Shatavari (Asparagus root) Gelatinous foods
Dang gui (Chinese angelica) Black beans, kidney beans
Butter
Nuts, seeds

Ovulation

Liver Qi Milk thistle Aerobic exercise
Blood Chai hu (bluperum) Sexual activity
Goji berries Expressing emotions
Peony root Beet greens
Damiana Butter

Luteal

Kidney Yang Black beans Warm baths
Spleen Qi Cinnamon or Maca Avoiding chills or cold food
Dried ginger l Red meat
Walnuts Yellow, orange and black foods
Yams Carrot juice
Vitex Magnesium and zinc

Premenstrual

Liver Qi Free and Easy Wanderer Movement
(Xiao yao san) Expressing emotions
Cilantro Walks in green forests
Licorice

Menstrual

Blood Topical frankincense Warmth
San qi (notoginseng) Moonlight walks by sea
Turmeric Mild movement
Rest
Beets
Menstrual Cycle
Image via Wikipedia

Now normally I wouldn’t go for simple herbs given as examples in the chart above.  I give herbs in formulas that are individualized for the client.  The client may have a pattern of phlegm or dampness or yin deficiency which would need addressing in all stages.  In formulas for all stages I would probably include an appropriate adaptogen to balance the HPA-Ovarian axis like ginseng or shatavari or eleuthero. The body will do better overall if its own balancing is engaged rather than being just pushed, but since women tend to come to me towards the end of their reproductive cycle, I don’t rely upon adaptogens alone.

I may use Yang-supporting herbs during the Yin phase since Yin engenders Yang.  And I never tonify Yang without also tonifying Yin.  If you look at the chart on the right you see that there is some level of progesterone during the follicular, estrogen-dominant phase and quite a bit of estrogen during the progesterone-dominant luteal phase.  (This fits Yin/Yang theory quite well.)

The other reason for staging formulas is that certain formulas useful for fertility may be contraindicated in pregnancy.  For instance if a woman has blocked fallopian tubes or phlegm stasis PCOS, I would want to use herbs that would be too strongly moving to be used in pregnancy.  The best way to do this is to have the woman use a barrier method of birth control for two to three cycles.  However in women who fear that they have few cycles left, we may only give the formula up until ovulation then stop during the time that she might get pregnant, starting up again as menstruation begins.

Women are cyclic creatures, with hormonal tides.  It makes sense that we follow those tides when treating herbally, ensuring that there is enough Yin, Yang, Jing and Blood to support a healthy pregnancy.  And staging herbal formulas to support those tides can give a woman what she  needs to nourish a healthy baby.

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Full Fat Dairy Helps Ovulation in the Infertile

Women who eat at least one portion of high-fat dairy food per day have more productive ovulation, by 27% than women who eat low-fat dairy. Women who eat 2 servings or more of low fat dairy have 85% more ovulation-related infertility.  Is it the dairy, the fat, or a combination?

‎”The risk of anovulatory infertility was found to be 27 percent lower in women who ate at least one portion of high-fat dairy food per day compared with women who had one high-fat serving of dairy per week, or even less. Women who ate two or more portions of lowfat dairy foods a day increased their risk of ovulation related infertility by 85 percent.”      Human Reproduction 2007;doi:10.1093/humrep/dem019.

Butter, A Source of CLA
Butter, A Source of CLA

We live in a world where low fat is treated as the holy grail of health, yet we forget that fats and fats alone contain certain essential nutrients, including those used to form hormones used in reproduction.  The fat from pasture-raised cows contain  has as much as five times the CLA (a fatty acid which is a potent anti-cancer agent, muscle builder, and immunity booster) as fat from grain-fed cows.  The Omega 3 essential fatty acids are found in similar proportions to deep sea fish.  Grass-fed milk contains rumenic acid (a CLA), DHA, vaccenic acid, branched chain fatty acids, butyric acid, lecithin, cysteine-rich whey proteins, calcium, iodine and vitamin D all of which have value from reducing cancer to increasing fertility.

Butterfat contains glycospingolipids, a special category of fatty acids that protect against gastro-intestinal infection, which would be protective during pregnancy.  Raw butter is the only source of an anti-stiffness factor which prevents hardening of the arteries, cataracts, and calcification of the pineal gland- and which may prevent stiffness and adhesions of the fallopian tubes.

There is a case to be made that one should not take milk, and by milk I mean organic grass-fed milk, unless it comes with all of its fat. The balance of the drink is quite different, and there are constituents that mimic insulin and can stimulate insulin-resistance about which I have written before.  Insulin resistance may affect the ability of sperm to penetrate the egg more than anovulatory infertility. Butterfat in the milk will slow insulin spikes, since we know that having some fat in the meal will lower an insulin curve after eating. The second statistic about two servings or more of nonfat dairy causing 85% more anovulatory infertility may indicate that there is an additional mechanism.

But is it the lack of milk fat or the lack of fat altogether that causes a reduction in ovulation?  The study was not clear.  Women who tend to drink low fat milk also tend to reduce fat overall in their diets.  And I see women all the time who are thin, cold and infertile who have very little fat in their bodies or in their diets, usually of non-animal origin. Fat is needed for reproduction.

Among hunter-gatherers, fat is the preferred part of meat.  Inuit hunters will frequently eat the vitamin-rich fatty organs and fat, giving the muscle meat to their dogs.  Fat is what forms your brain, your hormones and allows your cell membranes to function.  And animal fat like the important Omega 3s, DHA and EPA, are not easily converted from plant-based forms- in fact a significant portion of people lack the genetic mechanism to convert plant fats to these essential animal fats, which is why flaxseed oil is not a good substitute for fish oil.

DHA Molecule
Image via Wikipedia

I think that fats, particularly animal fats, are an important factor in fertility.  Fat is the substance of  the phospholipid bilayer that surrounds cells, including eggs, and lets nutrients and sperm through the membrane.  Fat in the form of cholesterol makes up the building blocks of hormones needed to trigger ovulation and implantation.   Young women who have very low fat in their diets and very little body fat frequently lose their menstrual periods and suffer bone loss due to lack of estrogens.  This of course leads to fertility problems.