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Useful Supplements for Parkinson’s Disease: Part 3

Dietary supplements, such as the vitamin B sup...
Dietary supplements, such as the vitamin B supplement show above, are typically sold in pill form. (Photo credit: Wikipedia)

This is part 3 of my series on nutrition and Parkinson’s Disease.  Part One and Part Two can be  found preceding, focusing on foods to eat or to avoid.  This section is on supplements.

While Dr. Terry  Wahls‘ experience with MS shows food to be more effective than supplements at providing nutrition for neurological diseases, there is a place for supplementation with vitamins and minerals, provided they are taken together with food to make up for deficient nutrients in our foods.  Paul Bergner researched the decline of minerals in the diet due to modern agricultural practices which have strip mined the soil and reduced food value in his book, The Healing Power of Minerals, Special Nutrients, and Trace Elements (out of print.)  Most minerals not included in the standard NPK commercial fertilizer declined between the mid 1970s and mid 1990s by 30% according to USDA data (and who knows since then), notably magnesium, calcium and iron.  Trace minerals often disappeared entirely: the boron in apples in the 1940s is  no longer present.  An apple a day in 1929 would be equivalent to nearly 30 a day today  in terms of iron.  So while nutritional supplements should not be relied upon alone, since they do not capture the full spectrum of antioxidants or special nutrients, they can fill some holes in the diet, particularly minerals which affect neurotransmitters like dopamine and serotonin.

Vitamins are made by plants from the sun so will not be deficient when first picked but can be destroyed in transport.  New hybrid fruits and vegetables often feature diminished nutrition along with their sweet milder flavors.  Lettuce has largely lost its bitterness, which means it is less effective at stimulating digestive juices, further reducing nutrient absorption.  The same goes with a variety of fruits and vegetables.

The taste of food is not merely aesthetic.  Tastes stimulate the body to prepare for nutrients.  Bitter tastes cause the secretion of hydrochloric acid (which closes the esophogeal sphincter preventing reflux)  and bile, which helps break down fats and  protein and moves the intestine.  Since 80% of serotonin and other neurotransmitters are made in the gut, stimulating digestive juices with something bitter can prevent or ameliorate depression found in Parkinson’s.  A bitters formula, biting down on lime peel, a radicchio salad or grapefruit before the meal can start digestion properly and will also regulate blood sugar which is of interest in Parkinson’s’ disease.  Bitters must be tasted to stimulate digestion, but do not require large amounts, so do not use pills or capsules. Food or tinctures work better.

It is important to eat looking at the health of the mitochondria, the energy powerhouses in cells, especially brain cells.  There are many aspects of this that warrant an article of its own.  A protein in the body called Parkin is believed to detect, and then clear out, damaged mitochondria from the cell. In PD cases associated with mutations in another protein called PINK1, however, Parkin doesn’t seem to do its job, and it’s thought that the damaged mitochondria that remains might lead to the cell death that causes the disease.  A number of supplements are chosen to benefit the mitochondria.

While the supplements below can be beneficial for most it is important to avoid a “one size fits all” approach.  People with Parkinson’s (PWP) differ significantly in their symptoms, medications and health conditions and they need to coordinate with the help of a doctor or trained pharmacist to make sure that effective treatment is not compromised.  Minimal research has been done on nutrients, and nothing can be said to be a cure.  But there are certainly supplements that can make PWP maximize their health.

Vitamins and minerals can be taken at the same time as foods while amino acids and herbs should be taken an hour before or two hours after meals.  Important supplements, vitamins and minerals include:

  • Probiotics.  Recent research shows that Parkinson’s disease affects the gut/brain axis and that when PWP have more enterobacteria the worse they get. Probiotic bacteria help outcompete enterobacteria and improve absorption of other nutrients.  I like the well-researched but often forgotten Saccharomyces bloulliardi and Pharmax’s human lactobacillis strain
  • Vitamin B Complex including NADH.  When Parkinson’s disease patients took 30 mg of vitamin B 2 three times each day over a period of six months, they had better motor capacity,( though these participants also  no longer ate red meat, according to the University of Michigan Health System.) NADH, an active type of vitamin B 3, helps with increasing the amount of dopamine in the brain.  Methyl folate is the preferred form of the B vitamin, folic acid.  Do not look for high Vitamin B complex levels as they will wash out, and too much B6 can interfere with Parkinson’s medication. Instead take a low dose  3 times a day:  30mg three times a day of a Vitamin B complex is sufficient but NADH, methyl folate and B12 may require separate supplementation.
  • Sublingual Vitamin B12, especially in the form of Methylcolbalamin, a form of bio-active B12 that is well absorbed and crosses the blood brain barrier.   This makes it suitable for brain-nerve disorders. It is the form of vitamin B12 active in the central nervous system, necessary for cell growth and replication. In some people the liver may not convert cyanocobalamin, the common supplemental form of vitamin B12, into adequate amounts of methylcobalamin needed for proper neuronal functioning. Methylcobalamin may exert its neuroprotective effects through enhanced methylation, acceleration of nerve cell growth, or its ability to maintain already healthy homocysteine levels.  1000 micrograms.
  • Fish or cod liver oil to provide 1000 mg of DHA (about 5 capsules or a teaspoon of Carlson’s lemon flavored fish oil which you can use to wash down other supplements.)  Make sure the oil is not rancid, which can be tested by smell. This reduces the inflammation that drives Parkinson’s. Blue Ice is another source of fermented fish liver oil that I recommend Vegetarian sources of Omega 3 oils like flax seed or chia must be converted to DHA, which is genetically impossible for a significant proportion of the population, is difficult for older patients and requires as much as 30 times the dose in those who can use it. There may be marine seaweed DHA.
  • Vitamin D3 should be taken by PD patients as few of them have sufficient sun unless they live south of Atlanta and are regularly out of doors without sunscreen at noon.  While most Americans are deficient in the vitamin, actually a hormone with hundreds of body functions, PD patients have even lower average levels.  In a long term prospective Finnish study participants who had the highest levels of serum vitamin D had a 67% lower risk of developing Parkinson’s than those in the lowest 25% of the group studied after 29 years.  People differ significantly in their ability to absorb Vitamin D and how fast it breaks down so optimum levels (50-100 ng/ml of  25 Hydroxy D) must be determined by blood testing.  It usually takes over 10,000 iu of the vitamin daily to budge numbers but people with many diseases need more, especially those who work indoors, are fat, elderly or  suffering from disease.  I needed 50,000 iu per day, twice the physiological dose one would get from the sun, to get to the low 50s after 10,000 iu for 6 months didn’t work.  It took 3 months to get there from the low 30s.  (I monitored high intake with quarterly blood tests.) In some PWP improvement is due to general health while PWP with certain Vitamin D receptor genotypes showed improvement in symptoms according to a small scale clinical trial, conducted by researchers at the Jikei University School of Medicine in Tokyo, where 114 people with Parkinson’s were randomly assigned to take a modest 1200 iu vitamin D supplement or a placebo during a one-year period. Those people with particular gene versions of the Vitamin D receptor called Fokl TT and Fokl CT benefited from the vitamin D supplement when compared with placebo. But those with another genotype called Fokl CC did not.  (At higher levels even those might have responded.)  Nonetheless proper Vitamin D status is essential for general health and makes everything work better.
  • CoQ10 plays an important role in the mitochondria and is also a potent antioxidant. In a multi-center trial published in 2002, patients with early PD took either a placebo or Coenzyme Q10, at 300mg to 1200mg per day. The results showed that CoQ10 was well tolerated and was safe at these doses. Over a sixteen-month period those PWPs who were on the higher dose showed slower disease progression than the others. Currently, a much larger trial (the QE3 trial) is underway to truly determine the role of CoQ10 in the treatment of PD. This trial is testing doses of 1200mg and 2400mg daily.
  • Glutathione, a compound with multiple effects on nerve cell metabolism as well as a powerful antioxidant, is of particular interest for PWPs because of studies showing its depletion in the substantia nigra (the site of major nerve cell damage in PD). Although laboratory tests are promising, it is still not clear what is the best way for PWPs to take this since oral doses are relatively ineffective unless liposomal.  Dosages and long term effects are not well determined.
  • Zinc participates in the superoxide dismutase and zinc-thioneine enzymes to reduce oxidative stress in the brain and oxidative stress is believed to reduce dopamine production. Zinc‘s role in inciting or inhibitory responses is not clear.  Like all metals it should be used conservatively.
  • Magnesium  is involved in a number of crucial bodily functions, from the creation of bone to the beating of the heart and the balance of sugar in the bloodstream, of special interest in Parkinson’s dementia.  Magnesium is a particularly crucial element for mediating the vital functions of the nervous and endocrine systems; it helps maintain normal muscle and nerve functions, reduces tremors,  keeps heart rhythm steady, supports a healthy immune system, prevents depression, and keeps bones strong. Magnesium also helps regulate blood sugar levels, promotes normal blood pressure, prevents or treats constipation. and is known to be involved in energy metabolism and protein synthesis.In addition, magnesium stimulates activity of B vitamins,assists in clotting of blood, relaxes the muscles, aids in metabolism of carbohydrates and minerals, helps the body maintain a regular heart rhythm, and plays a central role in the formation of ATP (adenosine triphosphate), the mitochondrial-derived fuel on which the brain (and body) runs.  Magnesium balances out the potentially toxic increased levels of calcium in the cytosol.  The forms used should be chelated (end in “ate” like citrate or orotate) but there is a lot of individuality on which forms are good and switching can be done if one form doesn’t work.  Magnesium theronate crosses the blood brain barrier but is expensive so I combine.  I generally suggest 800 mg of magnesium citrate to start.  Topical magnesium chloride also  known as magnesium oil can be applied twice a day when diarrhea from oral magnesium  is a problem.  Most Americans are deficient in magnesium.
  • Iron can calm  some spasms if deficient, but must be used with care in Parkinson’s.  Iron is accumulated in different brain regions in presence of neuropathologies and increased levels of iron were found in the substantia nigra of patients with Parkinson’s. At this level, iron works with neuromelanin inducing oxidative stress and death of the dopamine-making neurons. Liver is better than supplements if iron is deficient and low dose tincture of Rumex crispus (Yellow  dock) to gastric tolerance allows more efficient use of iron without increasing the mineral itself.  Start at 10 drops twice daily of a standard 1:5 tincture and work up gradually.
  • Silica, appears to have the effect, as silicic acid,of reducing the bio-availability of aluminum, avoiding its deposit in neurofibrillary tangles which is associated with dementia.  Horsetail weed supplements provide this in a bioavailable form.
  • Creatinine increases levels of phosphocreatine, an energy source in the muscle and brain, and in experimental studies it protects against nerve cell injury. The National Institute of Neurological Disorders and Stroke (NINDS) has now funded a multi-center pilot study of creatinine (along with another agent, minocycline) in people with Parkinson’s. For PD, doses of 5 to 10 grams daily are under study.  Creatinine should be used cautiously by persons with impaired kidney function.
  • Citicholine (CDP choline, cytidinediphosphocholine) CDP choline, also known as citicoline, is often used by victims of stroke or head trauma. It may also have benefit in memory loss and PD.  CDP choline may help repair damaged nerve cells in brains, including those that produce dopamine. CDP choline may also increase levels of glutathione, an antioxidant.  Initial studies of CDP choline in PD suggest it may be most beneficial for the symptoms of rigidity and bradykinesia. Doses of 500 mg to 2,000 mg daily, either taken orally or given as an injection, have been used. The most common side effect reported with CDP choline is slight stomach upset. Use as directed on the supplement bottle
  • Phosphatidylserine was found by Tel Aviv University’s Department of Human Molecular Genetics and Biochemistry to improve the function of rat genes involved in disorders such as familial dysautonomia and Parkinson’s disease. Phosphatidylserine has already been .. The substance contains a molecule known to be essential in transmitting signals between nerve cells in the brain, and mitochondria require a constant and well-regulated supply of phospholipids for membrane integrity.  200-300 mg daily.
  • L-Tyrosine may be useful depending on your medication.  L-tyrosine, which is the precursor to L-dopa should improve Parkinson’s disease symptoms, as L-dopa converts into dopamine. But L-tyrosine can interfere in levadopa’s transport, and the University of Michigan Health System recommends that you do not combine the supplement L-tyrosine with the medication levadopa or take L-tyrosine instead. It may be useful when combined with St. John’s wort but more research needs to be done.
  • Alpha-Lipoic Acid & Acetyl-L-Carnitine may lower oxidative stress and a slowing of potential PD.  ALA is believed neuroprotective by increasing acetylcholine and lowering the damage from damaging proteins especially in the substantia nigra.  ALA may lessen the depletion of glutathione, lowering free radical damage, mitochondrial dysfunction and the death of dopaminergic neurons. Together with Acetyl-L-Carnitine, ALA has been found to protect in vitro human cells against mitochondrial dysfunction, oxidative damage and accumulation of alpha-synuclein and ubiquitin. Most notably, when combined, ALA and ALC worked at 100-1000-fold lower concentrations than they did individually.
  • SAM-e There is evidence suggesting that levodopa medication can reduce brain levels of SAMe. This depletion may contribute to the side effects of levodopa treatment, as well as the depression sometimes seen with  Parkinson’s disease. One study found that SAMe taken orally improved depression without changing the effectiveness of levodopa.  However, it is also possible that taking extra SAMe might have a long term interference with levodopa’s effectiveness. Contraindicated for bipolar disease and can interact with other antidepressants.  Deficiencies in methionine , folate , or vitamin B 12 can reduce SAMe levels so those supplements may help prevent depression. DMT is another potential precursor.  SAM-e is not found in appreciable quantities in foods, so it must be taken as a supplement by itself.  200-400 mg taken 3 to 4 times per day.
  • 5-HTP may help with depressive symptoms in Parkinson’s disease when combined with Levadopa and Carbidopa but get appropriate pharmaceutical advice.  Less expensive than SAM-e.
  • Melatonin can be taken an hour before bedtime if you have trouble sleeping.  Try not to use melatonin frequently as it is a hormone your body should make.  Sleep hygiene (no late TV or computer, low light an hour before bed, a hot bath) and essential oil of lavender smelled in bed are better.
  • EDTA orally can help remove heavy metals gradually. While IV chelation has not been found (or disproven) to be useful for Parkinson’s due to heavy metal toxicity, oral EDTA chelation is inexpensive and unlikely to cause harm and usually benefits most people.  The idea of using a chelator for Parkinson’s disease is not unreasonable: we know iron accumulates in the Parkinsonian brain, and iron seems to accumulate in important brain areas known to be part of the neurodegenerative process – including the substantia nigra.  Additionally, there are a few animal experiments that have shown a protective effect of chelation against the development of Parkinson’s disease.  Take as directed on the bottle.  Suppository form show no additional benefits and are quite expensive. Read Dr. Gary Gordon for more.
  • Trace mineral concentrate, netttles or seaweed provide trace minerals no longer found in food. I squirt 10 drops of my trace mineral concentrate into my grapefruit juice or a day’s ration of coffee.  Eating nettles grown on good soil or clean seaweed also provides trace minerals.

Do not take all supplements.  Most people will benefit from magnesium, turmeric, fish oil, Vitamin D,  B vitamins and trace minerals.  Take melatonin only if you have sleep problems that do not respond to sleep hygiene suggestions and lack of sleep makes you dysfunctional.  Don’t take iron unless you test low and also have leg cramps that do not respond to magnesium, blood sugar control, massage and exercise.  Exercise for circulation before using supplements. Walk in sunlight out of doors and exercise for depression before using supplements. Use detoxification supplements for a course of treatment which could be three months:  take organic meals, seaweeds, milk thistle, turmeric and EDTA, while doing dry brush massage and infrared saunas.  Consult with your doctor, pharmacist, acupuncturist or naturopath to make sure you are not working at cross-purposes.

Herbs

Herbs are generally a safe way to strengthen and tone the body’s systems and as complex organic substances they tend to have cofactors and buffers. As with any therapy, you should coordinate treatment from a trained herbalist ( look for titles like RH (AHG), NCCAOM in Herbal or Oriental Medicine, an Oriental Medicine degree, MS degrees in Ayurveda, western herbs or equivalent study) with your MD and to diagnose the pattern of your problem before starting any treatment. You may use herbs as dried extracts (capsules, powders, teas), glycerites (glycerine extracts), or tinctures (alcohol extracts). It is generally best to take herbs in a form you can taste because the taste signals your body to use them. Unless otherwise indicated, you should make teas with 1 tsp. herb per cup of hot water. Steep covered 5 – 10 minutes for leaf or flowers, and 10 – 20 minutes for roots. Drink two to four cups per day. You may use tinctures alone or in combination as noted.

  • English: Turmeric root. Photo taken in Kent, O...
    English: Turmeric root. Photo taken in Kent, Ohio w  (Photo credit: Wikipedia)

    Ginkgo biloba 80 mg two times per day or 60 mils three times a day in tincture or liquid extract form.  Ginkgo leaf extract is an antioxidant that improves blood flow to the brain and may help with dopamine delivery.

  • Turmeric is an adaptogen which means it will balance your hormones and immune system and is nontoxic at  normal doses.  It helps with energy, liver detoxification, pain reduction and improved circulation.  In India it is considered a panacea herb.  I do not suggest taking it in curcumin capsules, even with bioperine from black pepper which enhances circulation.  Instead cook liberally with it (curries anyone?) or take turmeric honey on days when you don’t.
  • Mucuna pruriens contains levodopa. One small study showed that it had better results than the form of levodopa given as prescription medication. Doses ranged from 22.5 – 67.5 g per day divided in 2 – 5 doses. More studies are needed. Do not take cowhage without your doctor’ s supervision, especially if you already take levodopa. –
  • Brahmi (Bacopa monniera ) is an Ayurvedic herb that is often used to treat people with Parkinson’s. Studies suggest that it improves circulation to the brain, as well as improving mood, cognitive function, and general neurological function. Dosage guidelines vary, but some practitioners suggest 100 – 200 mg twice daily.
  • Milk thistle helps with liver detoxification and may be useful for dealing with high level toxins or side effects from medication. Milk thistle should be taken before meals with a tall glass of water. The usual dose is 70 mg to 140 mg three times daily.

Homeopathy

Homeopathy when it works, depends on resonance.  Unlike foods, meds and herbs which can allow significant improvement even when there is not perfect match with the patient, homeopathy appears to either work or it doesn’t at all.  Because of this you should consult a trained homeopath who can determine the right remedy for you and change it when your symptom picture (hence resonance) changes.

  • Argentum nitricum — for ataxia (loss of muscle coordination), trembling, awkwardness, painless paralysis
  • Causticum — for Parkinson’s with restless legs at night
  • Mercurius vivus — for Parkinson’s that is worse at night, especially with panic attacks
  • Plumbum metallicum — especially with arteriosclerosis
  • Zincum metallicum — for great restlessness, and depression
  • Mag-phos-for trembling; shaking of hands, cramps in calves, feet very tender. Twitching,worse on right side

Combined R-alpha lipoic acid and aetyl-L-carnitine exerts efficient preventative effects in a cellular model of Parkinson’s Disease  J Cell Mol Med. 2010 Jan;14(1-2):215-25. doi: 10.1111/j.1582-4934.2008.00390.x.

Nutritional Supplements and Vitamins: Alternatives to Help Parkinson’s Disease? Parkinson’s Disease Foundation

Low vitamin D concentration exacerbates adult brain dysfunction Am J Clin Nutr 2013 97: 5 907-908

EDTA and Chelation Therapy: History and Mechanisms of Action, an Update Garry F. Gordon, MD, DO, MD(H)

Calcium, copper, iron, magnesium, silicon and zinc content of hair in Parkinson’s disease  Journal of Trace Elements in Medicine and Biology 19 (2005) 195–201

Nutrition for Parkinson’s Disease acupuncturebrooklyn.com

How to Make Turmeric Honey for Inflammation acupuncturebrooklyn.com

 

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Nutrition for Parkinson’s Disease- Part 1

Nutrition for Parkinson’s Disease has four components: What to Eat, What Not to Eat, Useful supplements and How to Eat, given symptoms of the disease.  This will be a four piece series.  Some of it is basic: the foods and superfoods that enrich the diet.  Some is specific to the typical complaints from either the disease, the medications and the often restrictive lifestyles that PD patients often adopt.   And the how-to acknowledges that the disease creates some physical problems that adaptive devices might help.

Mucuna
Mucuna in flower, source of L.Dopa (Photo credit: Wikipedia)

Nutrition for Parkinson’s Disease Part 1:  What to Eat

People with Parkinson’s have some extra requirements in their diet.  Because shaking can burn calories, it is easy to become underweight, although that is not universal.  Yin deficiency, a kind of dehydration or wasting, is generally seen in symptoms like shaking, muscle spasms, constipation, poorly nourished muscles and skin, as well as dehydration.  Blood deficiency can be seen with pale skin, lips and tongue as well as with muscle wasting. While we have limited knowledge of what causes the substantia nigra to stop making dopamine, it is likely that missing nutrients will be implicated in both the production of dopamine and the preservation of brain cells. People with Parkinson’s often suffer from constipation and muscle  spasms. So what should you eat?

  • Berries and other fruits-  While people with Parkinson’s who are not overweight can eat fruit rather freely, it is best to deal with nutrient-dense berries.   Blueberries, huckleberries, goji berries, blackberries, raspberries, organic strawberries,  pomegranates, and cherries all pack a deeper nutritional punch than apples, pears and bananas.  All are useful, but especially the berries which are rich sources of flavonoids.  Blueberries and organic strawberries can reduce depression, improve memory and slow neuro-degeneration. Goji berries are especially high in antioxidants and can build blood.  Cranberries may protect the urinary tract. Tart cherries can help insomnia with their melatonin. Berries can pack in the nutrition especially as swallowing becomes more difficult.  Go for organic, especially with strawberries and other berries because chemicals in pesticides can be linked to Parkinson’s. All fruits provide fiber which can counteract constipation. 1/2-1 cup daily.
  • Purine-rich foods which break down too uric acid and then urates:  The chemical urate, a potent antioxidant which is known to cause gout in excess, appears to slow the progression of Parkinson’s disease.  Foods that make uric acid include:  fructose, asparagus, beer, heart, herring,mussels,yeast, smelt, sardines, and sweetbreads.  Just don’t overdo it, especially if you are prone to gout or insulin resistance.  A serving a day, but take it in the evening if you are on Levodopa or Carbodopa.
  • Fatty fish or fish oil including halibut, sardines, wild Alaskan salmon, anchovies and herring are rich in the DHA and EPA, Omega 3 fatty acids which go to the brain and help guard against dementia which affects some 40% of people with Parkinson’s.  Fish oil improves cognition, protects against depression, boosts the immune system,relieves arthritis and protects the heart.  I do not find flax oil as effective as fish or cod liver oil- it can require 30 times the dose, goes rancid very rapidly and some 30% of the population cannot convert it to DHA.  (DHA makes up 20% of grey matter in the brain.)  If you eat fish, eat the skin and check Seafood Watch to make sure that mercury levels are low. Beef that is 100% pasture-raised on grass has a fat profile similar to deep water fish but conventionally grain-raised CAFO beef does not.  Otherwise get cod liver or fish oil and take enough to get 1000 mg of DHA. Since that can be 5 capsules, I generally get Carlson’s lemon-flavored fish oil or Green Pasture’s cinnamon fermented cod liver oil and use it to wash down supplements.
  • Iron is linked to dopamine production.  Patients with Parkinson’s have lower levels of dopamine produced by the substantia nigra and may respond to iron administration. Iron, as a cofactor in dopamine production, plays a central role in the etiology of the disease. Low dopamine can cause other neurological problems such as restless leg syndrome and muscle spasms.  Judging from the Parkinson’s people I see, Blood Deficiency is pretty  widespread. I recommend pasture-raised organic red meat, liver once a week,and dark green and dark red vegetables. (Chlorophyll is hemoglobin with magnesium at the center instead of iron, but usually has non-heme iron as well.)  To increase iron absorption, tincture of Yellow dock (Rumex crispus) given in drop doses to stomach tolerance, can be helpful. However taking iron as a supplement can be ineffective (hard to absorb), hard on your heart or absorbed by bad gut flora.  Dr.Campbell-McBride advises against it :

 Most people with abnormal gut flora have various stages of anemia. It is not surprising. They not  only can’t absorb essential for blood vitamins and minerals from food, but their own production of these vitamins is damaged. On top of that people with damaged gut flora often have a particular group of pathogenic bacteria growing in their gut, which are iron-loving bacteria (Actinomyces spp., Mycobacterium spp., pathogenic strains of E. coli, Corynebacterium spp., and many others). They consume whatever iron the person gets from the diet, leaving that person deficient in iron. Unfortunately, supplementing iron makes these bacteria grow stronger and does not remedy anemia.” (Gut & Psychology Syndrome)

Vinegars made with live mothers are probiotic
  • Probiotic Foods help you develop good gut flora that can out-compete undesirable bacteria and to increase digestion.  Live blue cheese, yogurt, kefir, sauerkraut, kimchee, vinegar with a mother like Braggs, kombucha, unpasturized  pickles and olives, miso, fermented fish sauces and pickled vegetables should be taken at each major meal.  Pickles and pickle juice helps the body free up magnesium which can reduce cramps.  Other bacteria help absorb minerals.  I prefer food-based sources of probiotics because you eat them fresh, they come with their own prebiotics which feed them and tend to have a variety of organisms that may not be in pill form.  For instance, most probiotic pills only have lactobacillus or bifidobacteria but there may be another 500 species that are present in a healthy gut. If you do use probiotic supplements, look for them in a refrigerated case rather than a shelf.
  • Prebiotic foods feed the gut flora and can protect against iron depleting strains of bacteria.  Prebiotics like  fructooligosaccharide (FOS) and inulin feed the probiotic organisms and allow them to proliferate in the gut.  They ought to be in probiotic supplements to help keep them alive.  However your gut also needs to be receptive to them.  Rather than purchasing a prebiotic supplement, eat a serving of Jerusalem artichokes, asparagus, onions, leeks, burdock root, garlic (in quantity), shallots, jicama root, chicory or dandelion root, barley or yacón each day.
  • Nuts from trees are great sources of Vitamin E in its various forms and trace minerals, as well as good fats provided you eat them raw.  Roasting can easily change the fat profile and excessive conventional salt triggers indiscriminate consumption.  You will absorb nut nutrients better if you soak them overnight- you can puree them into nut butter with a little sea salt, toss them into salad or a stir fry or make your own nut milks. They are storehouses of important trace minerals:  Brazil nuts are high in selenium which can help the heart.  Peanuts which are ground nuts are significantly contaminated with aflatoxin, a known carcinogen that is twenty times more toxic than DDT. Since toxins can cause some Parkinson’s, avoid peanuts. 1 oz . per day of tree nuts.
  • Beans in general are good for Parkinson’s because the fiber levels are high enough to prevent constipation while providing protein, reducing blood sugar spikes and providing  protection from cancer. They can be consumed daily with herbs like rosemary or bay leaf to reduce flatulence and making them yourself will allow you to change the water enough to reduce that problem.  But there are two beans in particular which provide special protection against Parkinson’s:  fava beans and mucuna beans.   These beans contain levodopa, the same chemical in Sinemet, Madopar, Dopar, Larodopa, and other levodopa-containing medicines used to treat PD which means that adding them to a well-balanced prescription can be problematic, although they can sometimes substitute for all or part of a prescription. According to Dr. Jame’s Duke’s database the entire fava plant, including leaves, stems, pods, and immature beans, contains levodopa, with the highest concentrations in the flowers and sprouting bean. The amount of levodopa can vary greatly, depending on the species of fava and where it’s grown especially since it has been cultivated as a food rather than a medicine for most of its history.  Three ounces (about 84 grams or ½ cup every day) of fresh green fava beans, or three ounces of canned green fava beans, drained, may contain about 50-100 mg of levodopa. One small study showed that mucuna had better results than the form of levodopa given as prescription medication and anecdotal evidence shows it tends to work better than fava beans. Doses range from 22.5 – 67.5 g per day divided in 2 – 5 doses.  Neither bean should be taken by persons with Monoamine oxidase inhibitors (MAOI) or elevations in blood pressure may result.  If you have favism, a genetic susceptibility where you lack an enzyme called glucose-6-phosphate, eating fava beans could cause a condition called hemolytic anemia.  This is ruled out by a test but it is unknown if mucuna also causes this reaction.  Lacking either MAOIs or Favism, both beans are potentially good for people with  Parkinson’s who work with an herbalist and medical doctor.
  • Cruciferous Vegetables like broccoli, cauliflower, cabbage, kale, bok choi, kohlrabi, brussels sprouts and mustard, rutabaga and turnip greens help reduce estrogen dominance which reduces magnesium and vitamin B. A deficiency in magnesium causes muscle tightening and that causes people to experience  muscle spasms while deficiency in vitamin B can cause neurological problems like neuropathy.  Cruciferous vegetables are rich in zinc, vitamins A, B, C, D and E and  Indole-3-Carbinol (I3C) which is especially beneficial to estrogen metabolism. When I3C combines with stomach acid it creates 3,3-Diindolylmethane, or DIM. The metabolism of DIM overlaps with estrogen metabolism so that it promotes healthy estrogen metabolism.  Eat 2-4 servings daily within your 9 servings of veggies and berries.  They should be steamed or in the case of kale chips, dried with heat to protect the thyroid.

  • Coffee and Tea. Coffee has shown to be helpful at both preventing and slowing the progression of Parkinson’s disease in a dose-dependent way.   Coffee consumption is associated with 60% fewer cases of Parkinson’s Disease in one study. Caffeinated coffee is better than decaf and coffee reduces symptoms better than other sources of caffeine, indicating that caffeine alone may not be the protective mechanism. (Coffee is much more than caffeine, with magnesium and potent antioxidants like the chlorogenic acids.) Caffeine as an isolate incidentally was associated with better motor control but had very little effect on daytime sleepiness.  One caveat:  some people don’t do well on coffee and tend to self-select out of  the positive scientific studies (try making a coffee placebo!) Follow your own body.  Tea has general health benefits from catechins which are powerful antioxidants and at least one study showed a reduced risk of Parkinson’s disease.  There is some evidence that symptoms may be reduced with tea drinking, especially in studies of Asian populations.
  • Other Fluids:  Since dehydration is a problem, you need to drink.  Drinking more than a half cup at a time triggers the urinary reflex so does not hydrate your tissues.  So put your water in a bottle with a drink-through cap and sip it  through the day.  If you drink coffee or soda, assume that the caffeine will reduce hydration by 25% and tea or iced tea by 10%.  Don’t drink soda though, especially cola or artificially sweetened soda which contains potential toxins not known to be safe for Parkinson’s.  If water seems too plain, add a spear of melon and a sprig of mint, or sliced lemons or fresh rosemary and orange slices. Coconut water has a good balance of electrolytes and isn’t too sweet. You can also get fluids from fruits like watermelon or citrus.  But if you can get fresh vegetable juice with lots of greens, it would be better from a nutritional standpoint. Don’t forget good fats- think of oil floating on water to prevent evaporation.
Mai men dong (ophiopogon tubers) make a mild soup ingredient that strongly tonifies yin. Available at Chinese grocery stores.
  • Yin building herbs and foods:  Parkinson’s disease can be dehydrating, drying out skin, muscles, the colon and joints. This is referred to as yin deficiency and can develop into deficient (friction) heat as it progresses. You need to nourish your fluids and tissues and there are a number of “Chinese grocery store”  or food grade herbs and foods that can help.  Seaweeds should be included in the diet at least twice a week, but dulse, nori and kelp are also available as sprinkles that can be used like a flavored salt inbetween.  Seaweeds are good sources of trace minerals and iodine, since much of our healthy topsoil has blown out to sea.  A table spoon or two of slippery elm or marshmallow powder can be stirred into applesauce or oatmeal.  Mai men dong bulbs (opiophogon, liorope) are small, bland Chinese vegetables that nourish yin, go well in even western soup and can be found at Chinese grocery stores.  So can white lily bulb (bai wei), broken into small bulblettes.  Shatavari (asparagus tuber, tian men dong), the yin adaptogen food can be found online powdered, and can be used to thicken soups while nourishing fluids, hormones and tissues.  Oatmeal, millet, alfalfa sprouts, artichoke, asparagus, kelp, mung bean sprouts, okra; peas, potatoes, black beans, avocado, aduki beans, seaweed, string beans, sweet potatoes, tomatoes (especially tomato paste), water chestnuts, yam, zucchini, berries, apricots, pears, watermelon, fish and shellfish, pork (especially liver and kidneys), beef, goose and duck, coconut milk and nuts all will help keep you supple.  9 servings of  yin-tonifying fruits and vegetables a day.
  • Foods with B vitamins, especially B1 thiamine, B5 pantothenic acid, B9 folate, B12 cobalamin, B6 pyrodoxine help the mitochondria which power our cells . Foods high in B vitamins include purple and green kale, mushrooms, bok choy, collards, rare organ meats like liver, heart and tongue,  and very rare muscle meat.  Meats are better sources when organic and grass fed. However if you can’t find grass fed liver, the organ has numerous detoxification pathways so you are safe with conventional liver- akin to an apartment building with a full janitorial staff.  This is not true of other organs.
  •  Iodine is important for Parkinson’s.  It not only necessary for the production of thyroid hormone, it is also responsible for the production of all of the other hormones of the body. Adequate iodine levels are necessary for proper immune system function. Iodine contains potent antibacterial, antiparasitic, antiviral, and anticancer properties. Iodine deficiency disorder can result in mental retardation, goiter, increased child and infant mortality, infertility, and socioeconomic decline. There is evidence that Parkinson’s is more prevalent where iodine is missing in the soil and  in areas where goiters are frequent. Long-term iodine deficiency appears linked to abnormalities in the dopaminergic system that include an increased number of dopamine receptors. This raises susceptibility to dopamine oxidation which, in turn, causes deficiencies of the antioxidant enzymes Copper or Zink superoxide dismutase, glutathione peroxidase and catalase. Dopamine deficiency also leads to elevated cytotoxic glutamate levels. Iodine is primarily found in seawater in very small quantities and solid rocks (usually near the ocean) that form when seawater evaporates. Iodine can also be found in seafood like halibut, salmon and shellfish and seaweeds like kelp, dulse, nori and hijiki. In fact, seaweed is one of the most abundant sources of iodine because seaweed has the ability to concentrate a large amount of iodine from the ocean water.  Seaweeds and seafood should be taken twice a week from low mercury sources.
  • Kitchen Spices:  There is often a loss of taste or smell with PD, and the use of strong spices like thyme, oregano, rosemary, ginger, tulsi (holy basil which is sharper than regular basil), cardamon and star anise are not only strong antioxidants but have penetrating flavor and can enhance cerebral circulation.  Do not forget that people with impaired taste can often perceive sour flavors like lemon juice, and vinegar or salty tastes (use seaweed granules, Celtic sea salt, Himalayan salt, iodized sea salt but no MSG.)  But turmeric is the king of anti-inflammatory spices.  Turmeric is an adaptogen that is strongly antioxidant and anti-inflammatory, which crosses the blood brain barrier and is neuroprotective. It is considered a panacea herb in Ayurvedic medicine. It is used in curries, soups, smoothies and in milk.  My favorite way to take medicinal doses is to take 10 oz. dried turmeric, 1/2 ounce freshly ground black pepper and 1/2 oz. ground ginger and mix well.  Then stir in a local honey until it has the texture of cookie dough.  Take a heaping teaspoon once or twice a day.
  • Good fats and oils:  Most seed oils or conventional cooking oils are too high in Omega 6 fatty acids at a time when the Omega 6/Omega 3 fatty acid ratio (PUFA) has gone from 2/1 to 30/1 today.  I recommend avoiding seed oils in favor of fruit oils like coconut oil and olive oil.  For cooking you need a more saturated oil like coconut oil that will not peroxidize (go rancid).  Ghee or animal drippings from grass-fed organic animals won’t distort under heat either compared to other oils.  For raw consumption, avocado, olive oil, black seed oil (see below) and lemon flavored fish oil are useful.  Coconut oil with its ketones has, according to case histories, caused a reversal of Alzheimer’s dementia so is worth considering for the cognitive decline of Parkinson’s or Lewy’s dementia.  It also offers protection from viral diseases.  1-3 tablespoons in oatmeal or other food.  It is being sold as an expensive functional food for Alzheimer’s.
Fresh Turmeric Root
  • Seeds are something I tend to avoid because we get too many Omega 6 oils in our diet, but a few are outstanding exceptions.  Flax seed, hemp seed, black seed and black sesame seeds all help nourish the bowel and help stop constipation, but each has specific virtues.  Flax seed has Omega 3 fats that some people can, through genetics and good lifestyle, convert to DHA and EPA.  You need to grind it to get the Omega 3s but the lignins in the skin do have some laxative benefit if you don’t. It goes rancid very fast and I recommend getting a coffee grinder and grinding immediately before eating.  It is good in oatmeal, over salads, in yogurt and preground in smoothies.  Hemp seed is currently either steamed or shelled  in the US so that it cannot grow.  It is a good source of Omega 3s but can also go rancid easily.  I prefer to make hemp milk or to use it in smoothies.  Black sesame seed (He zhi ma) tonifies both Liver and Kidney yin, nourishes blood and secures Essence. Black sesame seeds are very rich in iron, magnesium, manganese and copper. There are about 90 mg of calcium in one tablespoon of unhulled (black) seeds It is used in both food and medicine, especially for women and the elderly but since Parkinson’s patients of both sexes are often Blood deficient, don’t let tradition stop you.  Black seed (Nigella, black cumin) is used widely in the Middle East, as seed or oil.  It smells something like thyme and facilitates a healthy inflammatory response including cell signaling chemicals and hormone-like messengers.  Small amounts are put in string cheese and pickled Moroccan lemons, over salads, in pilaf or it is used medicinally.  According to Mahfouz and El-Dakhakhny:

Ladybug on Fava bean flower

“Two of the most volatile oils found in Black seed are nigellone and thymoquinone which were fist discovered in the herb in 1985. Nigellone offers both anti-spasmodic and bronchodilating properties which contribute to Black Seed’s potency against respiratory ailments. It also acts as an antihistamine which helps to reduce the negative symptoms of allergy sufferers. Thymoquinone contains excellent anti-inflammatory and analgesic properties. It is also a strong anti-oxidant and helps cleanse the body of toxins. Both nigellone and thymoquinone work in conjunction with one another to enhance Black Seed’s action against respiratory ailments. It also provides a healthy alternative to the more commonly prescribed cortisone based therapies used by allergy sufferers. Black seed provides a rich supply of polyunsaturated fatty acids. These ingredients play a key role in daily health and wellness. They help to regulate the metabolism, carry toxins to the skin’s surface for elimination, balance insulin levels, regulate cholesterol, improve body circulation, and promote healthy liver function. A deficiency in polyunsaturated fatty acids can lead to a wide number of health problems including nervous system disorders, uninhibited growths, and skin diseases. Black seed contains over 100 valuable nutrients. It is comprised of approximately 21% protein, 38% carbohydrates, and 35% plant fats and oils. The active ingredients of black seed are nigellone, thymoquinone, and fixed oils. Black seed also contains significant proportions of protein, carbohydrates and essential fatty acids. Other ingredients include linoleic acid, oleic acid, calcium, potassium, iron, zinc, magnesium, selenium, vitamin A, vitamin B, vitamin B2, niacin, and vitamin C.”

To summarize, you should get 7.5-8 servings of vegetables per day including at least 2 cooked cruciferous vegetables and the majority from the yin-tonifying list. Choose colored vegetables like butternut squash or cooked carrots for at least one serving.  At least one serving should be fermented to provide probiotic organisms (sauerkraut, kimchee) and twice a week sea vegetables (seaweeds). One serving of berries or tart cherries a day and one-half to one serving of other fruit.  Wild salmon or other fatty fish twice a week. Liver once a week. Organic pasture-raised meat, preferably organ meat on other days.  Beans especially black beans several times a week.  One ounce of tree nuts or nut butter daily. Organic eggs, preferably with a raw yolk daily. Spice your food with strong herbs, turmeric and ginger.  Sprinkle in flax seed, black seed, black sesame or hemp seed daily.  Two to four cups of coffee, two liters of water and two cups of other beverages.

Also see Kathrynne Holden‘s book on nutrition for people with Parkinson’s, Eat Well, Stay Well with Parkinson’s Disease which is available through Amazon or for download here.  While  she has somewhat more conventional food choices than make it through my Chinese medicine/herbalist lens, she has worked with PD for many years, has special expertise about food/medicine interactions and has dealt with malnourished people with Parkinson’s in both hospital and clinical settings.

I would be remiss if I did not mention Dr. Terry Wahls who suffers from MS but found a way of eating that took her from a tilt-recline wheelchair to riding horses and freely biking today.  She eats a variation on a paleo diet that is primarily vegetable based, specifically designed to support the brain and mitochondria. This is especially important for people with Parkinson’s, ALS, Huntington’s, PTSD, migraines, dementia and MS.  The vast majority of people do not eat to support life and need some significant changes. I urge you to take the time to watch her TED Talk.  If you want more, she has a video class on nutrition and the brain :

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Caffeine Halts Progression of Alzheimers

More research showing that coffee is not the brew of the devil. Not only does it prevent Alzheimer’s, it stopped the progression of the disease.  But a few caveats: it was caffeine, not coffee; it’s an awfully lot; it was mice, not people and no one asked them if they were jittery.Coffee mouse

From the Times of London:

Daily caffeine dose may delay progress of Alzheimer’s, researchers say

Hannah Devlin

Three large cups of coffee a day could help to slow the progress of Alzheimer’s disease and even reverse the condition, researchers say.

A daily dose of caffeine can suppress the degenerative processes in the brain that can lead to confusion and memory loss, a study in mice suggests.

Although drinking coffee has previously been linked to a lower risk of developing Alzheimer’s, this is the first study to suggest that caffeine can directly target the disease itself.

Alzheimer’s occurs when sticky clumps of abnormal protein in the brain called beta-amyloid build up to form plaques, impairing cognitive function. But mice with a rodent equivalent of the disease showed a 50 per cent reduction in levels of amyloid protein in their brains after scientists spiked their drinking water with caffeine.

The change was reflected in their behaviour as they developed better memories and quicker thinking. In the study, published today in the Journal of Alzheimer’s Disease, researchers from the University of South Florida studied 55 mice that had been genetically engineered to develop dementia symptoms identical to those of Alzheimer’s as they aged. Before treatment the mice, which were aged 18 to 19 months — about 70 years in human terms — had performed poorly in the memory tests.

Half the animals were given a daily dose of caffeine in their drinking water — equivalent to a human consuming about six espresso shots or 500mg of pure caffeine — while the other half continued to drink ordinary water. By the end of the two-month study, the caffeine-drinking mice were performing far better on tests of memory and thinking than mice given water. Their memories were as sharp as those of healthy older mice without dementia.

The scientists found that when the mice drank caffeinated water their blood levels of beta amyloid protein fell quickly. More importantly, the same effect occurred in the brain. Almost half the abnormal protein previously seen when the brains of Alzheimer’s mice were examined had vanished after two months.

The researchers hope that caffeine could present a safe, inexpensive treatment for dementia.

Professor Gary Arendash, a memory and ageing specialist who led the latest research, said that he wished to conduct human patient trials as soon as possible.

“The findings provide evidence that caffeine could be a viable treatment for established Alzheimer’s disease and not simply a protective strategy,” he said.

A study in 2002 found that people who consumed caffeine in mid-life were 60 per cent less likely to develop the disease.

About 417,000 people in the UK suffer from Alzheimer’s, and numbers are steadily rising. There is currently no cure and although drugs can help stabilise the condition, they are not widely available on the NHS until patients have advanced-stage disease and their effectiveness is relatively unpredictable from person to person.

Taking 500mg of caffeine in tablet form would be safe for most patients and would have relatively few side-effects, Professor Arendash said, although it is not clear how the dosage would translate from mice to humans.

Rebecca Wood, chief executive of the Alzheimer’s Research Trust, said that it was too early to say whether coffee or caffeine supplements could help Alzheimer’s patients.

“With no cure yet, research into treatments that could help people with Alzheimer’s is vital. [But] we need to do more research to find out whether this effect will be seen in people,” she said.

Getting perked up

How to get 500mg of caffeine a day:

2 x 250mg caffeine pills

3 x large espresso-based coffees

6 x cans of Red Bull

14 x cans of Coca-Cola

15 x cups of tea

7kg (16 lb) of chocolate

Source: US Food and Drug Administration, University of South Florida

See also:
http://news.bbc.co.uk/2/hi/health/8132122.stm
Excerpt:

When the mice were tested again after two months, those who were given the caffeine performed much better on tests measuring their memory and thinking skills and performed as well as mice of the same age without dementia. Those drinking plain water continued to do poorly on the tests.

In addition, the brains of the mice given caffeine showed nearly a 50% reduction in levels of the beta amyloid protein, which forms destructive clumps in the brains of dementia patients. Further tests suggested caffeine affects the production of both the enzymes needed to produce beta amyloid. The researchers also suggest that caffeine suppresses inflammatory changes in the brain that lead to an overabundance of the protein.

See also:  Science Daily article with citations and the mouse picture above.

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Caffeine Halts Progression of Alzheimer’s

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